Expression and Function of Keratinocyte Growth Factor and Activin in Skin Morphogenesis and Cutaneous Wound Repair

    December 2000 in “ ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings ”
    Hans‐Dietmar Beer, Marcus Gassmann, Barbara Munz, Heike Steiling, Felix Engelhardt, Kerstin Bleuel, Sabine Werner
    Image
    Studysummary This study reports that overexpression of activin in transgenic mice enhances granulation tissue formation during wound healing, highlighting a novel role for activin in cutaneous repair processes. Our plain-language summary of this paper — not a Tressless recommendation.
    The study highlighted the roles of keratinocyte growth factor (KGF) and activin in skin morphogenesis and wound repair. KGF, which is weakly expressed in normal skin but upregulated after injury, promotes keratinocyte proliferation, migration, and protection from oxidative damage. Activin, minimally present in nonwounded skin, is highly expressed in hyperproliferative wound epithelium and granulation tissue. Transgenic mice overexpressing activin showed enhanced granulation tissue formation, indicating its significant role in wound healing. The findings underscored the importance of both KGF and activin in the repair processes of injured skin.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results