Expression and Function of Keratinocyte Growth Factor and Activin in Skin Morphogenesis and Cutaneous Wound Repair

December 2000 in “ The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings ”

Hans‐Dietmar Beer, Marcus Gassmann, Barbara Munz, Heike Steiling, Felix Engelhardt, Kerstin Bleuel, Sabine Werner

keratinocyte growth factor KGF activin skin morphogenesis cutaneous wound repair keratinocyte proliferation granulation tissue hyperproliferative wound epithelium

TLDR KGF and activin are crucial for skin healing and repair.

The study highlighted the roles of keratinocyte growth factor (KGF) and activin in skin morphogenesis and wound repair. KGF, which is weakly expressed in normal skin but upregulated after injury, promotes keratinocyte proliferation, migration, and protection from oxidative damage. Activin, minimally present in nonwounded skin, is highly expressed in hyperproliferative wound epithelium and granulation tissue. Transgenic mice overexpressing activin showed enhanced granulation tissue formation, indicating its significant role in wound healing. The findings underscored the importance of both KGF and activin in the repair processes of injured skin.

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Overexpression of Activin A in the Skin of Transgenic Mice Reveals New Activities in Epidermal Morphogenesis, Dermal Fibrosis, and Wound Repair

research Overexpression of Activin A in the Skin of Transgenic Mice Reveals New Activities in Epidermal Morphogenesis, Dermal Fibrosis, and Wound Repair

204 citations, October 1999 in “EMBO journal”

Overexpression of activin A in mice skin causes skin thickening, fibrosis, and improved wound healing.

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