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GlossaryAmphiregulin

protein involved in cell growth and tissue repair

Amphiregulin is a protein that plays a crucial role in cell growth and healing. It binds to the epidermal growth factor receptor (EGFR) on cells, which can stimulate processes like tissue repair and hair growth. In the context of alopecia, understanding amphiregulin's function could help in developing treatments to promote hair regeneration.

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Transcription Factor SOX2-Induced Amphiregulin Inhibits Pressure Ulcer Formation via Suppressing Oxidative Stress After Cutaneous Ischemia-Reperfusion in Mice

research Transcription Factor SOX2-Induced Amphiregulin Inhibits Pressure Ulcer Formation via Suppressing Oxidative Stress After Cutaneous Ischemia-Reperfusion in Mice

April 2023 in “Journal of Investigative Dermatology”

SOX2 helps reduce wound size and pressure ulcer formation by suppressing oxidative stress and increasing antioxidant activity in mice.

research High Amphiregulin Expression Is a High-Risk Feature of Acute Graft-Versus-Host Disease of the Skin

April 2018 in “Journal of Investigative Dermatology”

High amphiregulin in the skin is a bad sign for acute graft-versus-host disease.

research Regulatory T-Cells: Potential Regulator of Tissue Repair and Regeneration

188 citations, March 2018 in “Frontiers in Immunology”

Regulatory T-cells are important for healing and regenerating tissues in various organs by controlling immune responses and aiding stem cells.

research Tregs: Where We Are and What Comes Next?

130 citations, November 2017 in “Frontiers in Immunology”

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

research Growth Factors in Hair Organ Development and the Hair Growth Cycle

90 citations, October 1996 in “Dermatologic Clinics”

Growth factors are crucial for hair development and could help treat hair diseases.

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