Evidence That the Satin Hair Mutant Gene Foxq1 Is Among Multiple and Functionally Diverse Regulatory Targets for Hoxc13 During Hair Follicle Differentiation

    July 2006 in “ Journal of biological chemistry/˜The œJournal of biological chemistry ”
    Christopher S. Potter, Ron L. Peterson, Jeremy L. Barth, Nathanael Pruett, Donna Jacobs, Michael J. Kern, W. Scott Argraves, John P. Sundberg, Alexander Awgulewitsch
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    TLDR The gene Foxq1, controlled by Hoxc13, is crucial for hair follicle differentiation.
    The study demonstrated that the gene Foxq1 is a downstream target of Hoxc13 and plays a crucial role in hair follicle differentiation, particularly in the medulla compartment. Using Hoxc13-overexpressing transgenic mice, researchers found that Hoxc13 influences the expression of various genes specific to different hair shaft compartments. The medulla-specific gene Foxq1, which is altered in satin mouse hair mutants, was shown to be essential for the expression of other medulla-specific genes. This suggests that Hoxc13 and Foxq1 work together in a regulatory pathway to control medulla differentiation, highlighting a potential interaction between Hox and Fox gene families in developmental processes.
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