The Nude Mutant Gene Foxn1 Is a HOXC13 Regulatory Target During Hair Follicle and Nail Differentiation

    December 2010 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Christopher S. Potter, Nathanael Pruett, Michael J. Kern … Alexander Awgulewitsch
    Studysummary This study suggests a regulatory model where HOXC13 activates Foxn1, affecting hair and nail differentiation, supported by similarities in Hoxc13(tm1Mrc) and Foxn1(nu) mice phenotypes and gene expression patterns.
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    Research cited in this study 18

    1. Desmoglein 4 Is Regulated by Transcription Factors Implicated in Hair Shaft Differentiation Differentiation · 2009
    2. Genetic Interplays Between Msx2 And Foxn1 Are Required For Notch1 Expression And Hair Shaft Differentiation Developmental Biology · 2008
    3. Smad4-Dependent Desmoglein-4 Expression Contributes to Hair Follicle Integrity Developmental Biology · 2008
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    8. FOXN1 Is Critical for Onycholemmal Terminal Differentiation in Nude (Foxn1nu) Mice ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2004
    9. Krtap16: Characterization of a New Hair Keratin-Associated Protein Gene Complex on Mouse Chromosome 16 and Evidence for Regulation by Hoxc13 Journal of Biological Chemistry · 2004
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    11. HOXC13 Is Involved in the Regulation of Human Hair Keratin Gene Expression Journal of Biological Chemistry · 2002
    12. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    13. The Nude Gene and the Skin Experimental Dermatology · 2001
    14. Overexpression of Hoxc13 in Differentiating Keratinocytes Results in Downregulation of a Novel Hair Keratin Gene Cluster and Alopecia Development · 2001
    15. Forkhead/Winged-Helix Transcription Factor Whn Regulates Hair Keratin Gene Expression: Molecular Analysis of the Nude Skin Phenotype Developmental Dynamics · 2000
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    18. Hoxc13 Mutant Mice Lack External Hair Genes & Development · 1998