TLDR HOXC13 is essential for hair and nail development by regulating Foxn1.
The study investigated the role of the Foxn1 gene in hair follicle and nail differentiation, identifying it as a regulatory target of the HOXC13 gene. It demonstrated that HOXC13 directly activated Foxn1, which is crucial for proper hair and nail development. Mutations in these genes led to defects in hair shaft organization and nail structure, as seen in Hoxc13 null and Foxn1nu (nude) mutant mice. The research highlighted the genetic interactions necessary for keratinocyte differentiation, contributing to the understanding of conditions like alopecia and nail dystrophies. Techniques such as DNA microarray analysis, co-transfection assays, and chromatin immunoprecipitation were used to confirm these findings.
35 citations,
December 2009 in “Differentiation” Desmoglein 4 is controlled by specific proteins that affect hair growth.
67 citations,
February 2009 in “Developmental Biology” Msx2 and Foxn1 are both crucial for hair growth and health.
28 citations,
October 2008 in “Developmental Biology” Smad4 is important for healthy hair follicles because it helps produce a protein needed for hair to stick together and grow.
65 citations,
September 2006 in “Journal of biological chemistry/The Journal of biological chemistry” The gene Foxq1, controlled by Hoxc13, is crucial for hair follicle differentiation.
86 citations,
October 2005 in “Experimental Dermatology” The Foxn1 gene mutation causes hairlessness and immune system issues, and understanding it could lead to hair growth disorder treatments.
58 citations,
December 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” The Foxn1 gene is essential for normal nail and hair development.
854 citations,
February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” Understanding hair follicle development can help treat hair loss, skin regeneration, and certain skin cancers.
