FOXN1 Is Critical for Onycholemmal Terminal Differentiation in Nude (Foxn1nu) Mice

November 2004 in “ The journal of investigative dermatology/Journal of investigative dermatology ”

Lars Mecklenburg, Ralf Paus, Zdeněk Halata, Lesley Bechtold, Philip Fleckman, John P. Sundberg

FOXN1 hair keratins onychocyte differentiation keratin 1 filaggrin keratohyalin granules nail matrix onycholemmal differentiation

Studysummary This study found that mutations in the Foxn1 gene in nude mice affect not only hair but also nail structure and differentiation, offering insights into nail hypergranulosis pathogenesis relevant to human nail diseases.

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