Primary Follicular Dystrophy With Scarring Dermatitis in C57BL/6 Mouse Substrains Resembles Central Centrifugal Cicatricial Alopecia in Humans

    September 2010 in “ Veterinary pathology ”
    John P. Sundberg, Douglas K Taylor, Gwendolen Lorch … Helen B. Everts
    Studysummary This study found that certain C57BL/6 mouse substrains have a genetic vulnerability to skin lesions resembling central centrifugal cicatrical alopecia in humans, potentially worsened by high vitamin A levels.
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    Research cited in this study 7

    1. Immunolocalization of Enzymes, Binding Proteins, and Receptors Sufficient for Retinoic Acid Synthesis and Signaling During the Hair Cycle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2007
    2. FOXN1 Is Critical for Onycholemmal Terminal Differentiation in Nude (Foxn1nu) Mice ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2004
    3. Hair Cycle-Specific Immunolocalization of Retinoic Acid Synthesizing Enzymes Aldh1a2 and Aldh1a3 Indicate Complex Regulation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2004
    4. Elastic Tissue in Scars and Alopecia Journal of cutaneous pathology · 2000
    5. Vesicle Formation and Follicular Root Sheath Separation in Mice Homozygous for Deleterious Alleles at the Balding Locus ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1997
    6. Angora Mouse Mutation: Altered Hair Cycle, Follicular Dystrophy, Phenotypic Maintenance of Skin Grafts, and Changes in Keratin Expression Veterinary Pathology · 1997
    7. Alopecia Areata in Aging C3H/HeJ Mice Journal of Investigative Dermatology · 1994