Primary Follicular Dystrophy With Scarring Dermatitis in C57BL/6 Mouse Substrains Resembles Central Centrifugal Cicatricial Alopecia in Humans

September 2010 in “ Veterinary pathology ”

John P. Sundberg, Douglas K Taylor, Gwendolen Lorch, Jim Miller, Kathleen A. Silva, Beth A. Sundberg, Derry C. Roopenian, Leonard C. Sperling, David E. Ong, Lloyd E. King, Helen B. Everts

primary follicular dystrophy scarring dermatitis C57BL/6 mouse substrains central centrifugal cicatricial alopecia CCCA follicular dystrophy inflammation granuloma formation vitamin A metabolism ADH4 enzyme DHRS9 enzyme

Studysummary This study found that certain C57BL/6 mouse substrains have a genetic vulnerability to skin lesions resembling central centrifugal cicatrical alopecia in humans, potentially worsened by high vitamin A levels.

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The study investigated primary follicular dystrophy with scarring dermatitis in C57BL/6 mouse substrains, finding that it closely resembled central centrifugal cicatricial alopecia (CCCA) in humans. Researchers observed similar clinical and histological features, including follicular dystrophy, inflammation, and granuloma formation. The study involved 200 C57BL/6J mice and identified potential links to vitamin A metabolism defects, particularly involving the ADH4 and DHRS9 enzymes. The findings suggested that these mice could serve as a valuable model for studying CCCA in humans and developing therapeutic strategies, although further research was needed to confirm the genetic and metabolic mechanisms involved.

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