Proliferative and Non-Proliferative Lesions of the Rat and Mouse Integument

    January 2013 in “ Journal of toxicologic pathology ”
    Lars Mecklenburg, Donna F. Kusewitt, Carine Kolly, Silke Treumann, E. Terence Adams, Kelly L. Diegel, Jyoji Yamate, Wolfgang Kaufmann, Steffen Müller, Dimitry M. Danilenko, Alys Bradley
    TLDR The project created a standardized system for classifying skin lesions in lab rats and mice.
    The document titled "Proliferative and Non-Proliferative Lesions of the Rat and Mouse Integument" from January 1, 2013, provided a comprehensive examination of various skin lesions in rats and mice, distinguishing between proliferative and non-proliferative types. It aimed to enhance understanding of these lesions' characteristics, crucial for toxicological pathology, and contributed to the broader knowledge of skin pathology in these animals, relevant for interpreting similar conditions in humans. The INHAND project standardized the nomenclature for classifying microscopic lesions, harmonizing terminology internationally. The document covered conditions like alopecia, ulcerative dermatitis, and dermatotoxicology, emphasizing the importance of combining clinical data with histomorphology for accurate diagnosis. It also discussed the impact of genetic factors, proper animal husbandry, and the differences in skin morphology between rodents and humans. The study highlighted the significance of histopathological analysis in diagnosing and understanding these lesions, providing detailed diagnostic features and differential diagnoses for various skin conditions and tumors.
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