TLDR The project created a standardized system for classifying skin lesions in lab rats and mice.
The document titled "Proliferative and Non-Proliferative Lesions of the Rat and Mouse Integument" from January 1, 2013, provided a comprehensive examination of various skin lesions in rats and mice, distinguishing between proliferative and non-proliferative types. It aimed to enhance understanding of these lesions' characteristics, crucial for toxicological pathology, and contributed to the broader knowledge of skin pathology in these animals, relevant for interpreting similar conditions in humans. The INHAND project standardized the nomenclature for classifying microscopic lesions, harmonizing terminology internationally. The document covered conditions like alopecia, ulcerative dermatitis, and dermatotoxicology, emphasizing the importance of combining clinical data with histomorphology for accurate diagnosis. It also discussed the impact of genetic factors, proper animal husbandry, and the differences in skin morphology between rodents and humans. The study highlighted the significance of histopathological analysis in diagnosing and understanding these lesions, providing detailed diagnostic features and differential diagnoses for various skin conditions and tumors.
29 citations,
November 2011 in “Veterinary pathology” The study found that mouse sweat glands develop before birth, mature after birth, and have specific keratin patterns.
56 citations,
September 2010 in “Veterinary pathology” Certain mouse strains develop a skin condition similar to a human hair loss disease due to genetic defects.
31 citations,
June 2010 in “Journal of dermatology” Hair bleaching causes significant damage to hair and skin.
92 citations,
November 2006 in “Proceedings of the National Academy of Sciences of the United States of America” BMP signaling controls hair follicle size and cell growth by affecting cell cycle genes.
38 citations,
November 2005 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” Understanding normal hair follicle development helps analyze abnormalities in mutant mice.
106 citations,
June 2005 in “Journal of Investigative Dermatology” The document concludes that assessing hair follicle damage due to cyclophosphamide in mice involves analyzing structural changes and suggests a scoring system for standardized evaluation.
23 citations,
June 2003 in “Journal of Investigative Dermatology Symposium Proceedings” Alopecia Areata is an autoimmune disease affecting hair follicles, influenced by genetic and environmental factors, with rodent models being essential for research.
86 citations,
December 2001 in “Experimental dermatology” Mutant mice help researchers understand hair growth and related genetic factors.
11 citations,
November 1998 in “Journal of dermatological science” Knocking out certain genes in mice helps understand skin and hair growth problems.
2 citations,
January 2018 in “Elsevier eBooks” Lipid nanoparticles improve drug delivery through the skin, offering stability, controlled release, and better compatibility with skin.
19 citations,
March 2011 in “Cutaneous and Ocular Toxicology” Some chemicals absorbed through the skin can cause serious health problems.
7 citations,
December 2011 in “Elsevier eBooks” The document concludes that early diagnosis and treatment are crucial for managing skin diseases in ferrets.
January 2024 in “The Indian Veterinary Journal” A young goat with skin issues improved with medication and supplements.
56 citations,
September 2010 in “Veterinary pathology” Certain mouse strains develop a skin condition similar to a human hair loss disease due to genetic defects.
