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Glossary Skin Toxicity

harmful effects of substances or treatments on skin

Skin toxicity, also known as dermatotoxicity or cutaneous toxicity, refers to the harmful effects that certain substances or treatments can have on the skin. This can include symptoms such as redness, itching, blistering, or more severe reactions like necrosis. It is a common side effect of some medications, chemicals, and radiation therapy, and is an important consideration in both medical treatments and product safety evaluations.

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Research

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research Skin toxicity determined in vitro by three-dimensional, native-state histoculture.

54 citations , March 1991 in “Proceedings of the National Academy of Sciences”

This study describes a gel-supported in vitro system for culturing skin samples that may effectively replace animal systems for toxicity testing, showing high correlation with in vivo skin toxicity measurements.

research Efficacy and Skin Toxicity Management with Cetuximab in Metastatic Colorectal Cancer: Outcomes from an Oncologic/Dermatologic Cooperation

42 citations , January 2008 in “Clinical colorectal cancer”

In this study, a combination of irinotecan and cetuximab showed varied response rates in metastatic colorectal cancer patients, with manageable skin toxicity that improved quality of life when treated collaboratively by oncology and dermatology teams.

research Skin toxicity of anti‐cancer therapy

19 citations , October 2008 in “Journal der Deutschen Dermatologischen Gesellschaft”

This article reviews the cutaneous reactions and characteristic skin changes associated with chemotherapy, radiation therapy, and new targeted cancer treatments, reporting no new clinical results.

research Skin toxicity caused by EGFR antagonists—An autoinflammatory condition triggered by deregulated IL‐1 signaling?

19 citations , September 2008 in “Journal of Cellular Physiology”

This article explores potential mechanisms of acneiform skin eruptions linked to EGFR inhibition in cancer patients, focusing on EGFR's role in controlling IL-1-dependent inflammation at hair follicles, but reports no clinical results.

research A novel approach to manage skin toxicity caused by therapeutic agents targeting epidermal growth factor receptor

4 citations , March 2012 in “Annals of oncology”

In this study, a combined therapy of nicotinamide and green tea polyphenols was reported to improve EGFR inhibitor-related skin toxicity and patient quality of life, suggesting it merits further investigation.

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Community Join

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community Tretinoin to counter-act Minoxidil's skin effects?

5 upvotes 6 years ago

Minoxidil may cause dark circles and affect collagen, and Tretinoin might help counteract these effects. Users suggest caution with Tretinoin due to potential Vitamin A toxicity and recommend using it sparingly with sunscreen and moisturizer.

community PP405 is NOT gray market jxl069

in Technology 26 upvotes 8 months ago

PP405 is a safer alternative to JXL069 for hair loss treatment because it penetrates the skin effectively and degrades in the blood, avoiding systemic toxicity. JXL069, when forced into the body, can cause dangerous side effects like lactic acidosis due to its inability to degrade safely.

community Finally Scalp Folliculitis-Free after 2 Decades of Suffering

64 upvotes 1 year ago

A 37-year-old male resolved scalp folliculitis by adopting a low-histamine diet and taking Vitamin A, Zinc, and Fish Oil, leading to better skin health and thicker hair. He warns about the potential toxicity of excessive Vitamin A intake.

community Isopropyl alcohol, instead of ethyl alcohol, for topical finasteride home-made serum?

1 upvotes 7 months ago

Isopropyl alcohol should not replace ethanol in homemade topical finasteride serums due to potential toxicity with frequent use. Denatured ethanol, also known as parfum or cosmetic alcohol, is a safer alternative.

community Tretinoin for some men(not all) can cause non-telogen effluvium hair loss

in Research/Science 5 upvotes 1 year ago

Tretinoin can cause non-telogen hair loss in some men by inducing catagen-like changes in hair follicles and through retinoid toxicity, especially when used with minoxidil. Some users report hair loss even when using retinoids on the face, while others experience benefits when combined with treatments like finasteride and minoxidil.

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Learn

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learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn Thymosin Beta 4

learn Melatonin

Can melatonin cause side effects on the skin or hair? Melatonin may cause hair loss or thinning in some users, but evidence is limited.

learn Scalp Micropigmentation

Does scalp micropigmentation work on all skin tones and hair colors? Scalp micropigmentation can be customized for various skin tones and hair colors.
Is scalp micropigmentation suitable for people with sensitive skin? Providers say scalp micropigmentation suits most skin types and describe patch tests, hypoallergenic pigments and a skin consultation for sensitive skin. These are provider claims rather than independent safety evidence, and pigment reactions remain a risk.

learn retinol

How does retinol improve scalp health and prepare the skin for other hair growth treatments? Retinol improves scalp health by promoting cellular turnover and reducing congestion.

learn Hyaluronic Acid

Does hyaluronic acid really hydrate the scalp, or is it mainly for skin care? Hyaluronic acid can hydrate the scalp, but its effectiveness may vary.

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Experts

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36
SMP Specialist
Noelle Skin
Nice, France

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