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    Glossary Skin Toxicity

    harmful effects of substances or treatments on skin

    Skin toxicity, also known as dermatotoxicity or cutaneous toxicity, refers to the harmful effects that certain substances or treatments can have on the skin. This can include symptoms such as redness, itching, blistering, or more severe reactions like necrosis. It is a common side effect of some medications, chemicals, and radiation therapy, and is an important consideration in both medical treatments and product safety evaluations.

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    1. Skin toxicity determined in vitro by three-dimensional, native-state histoculture. Proceedings of the National Academy of Sciences · 1991 · 54 citations
    2. Efficacy and Skin Toxicity Management with Cetuximab in Metastatic Colorectal Cancer: Outcomes from an Oncologic/Dermatologic Cooperation Clinical colorectal cancer · 2008 · 42 citations
    3. Skin toxicity of anti‐cancer therapy Journal der Deutschen Dermatologischen Gesellschaft · 2008 · 19 citations
    4. Skin toxicity caused by EGFR antagonists—An autoinflammatory condition triggered by deregulated IL‐1 signaling? Journal of Cellular Physiology · 2008 · 19 citations
    5. A novel approach to manage skin toxicity caused by therapeutic agents targeting epidermal growth factor receptor Annals of oncology · 2012 · 4 citations
    6. Targeted Treatments of Non-Small Cell Lung Cancer (NSCLC): Skin Toxicity Дерматовенерология Косметология · 2022 · 1 citations
    7. Skin toxicity induced by chemotherapy or molecular targeted therapy combined with immune checkpoint inhibitors in Asian patients: A literature review by the Japanese Pharmacist-led Oncodermatology Study Team International Journal of Clinical Oncology · 2026
    8. Skin Toxicity in Palliative Radiation Therapy Elsevier eBooks · 2017
    9. Prophylaxis and Management of Skin Toxicities Breast care · 2019 · 15 citations
    10. When bugs and drugs conspire: driving acneiform skin toxicity 2020 · 1 citations
    11. Semiology of skin toxicity associated with epidermal growth factor receptor (EGFR) inhibitors Supportive Care in Cancer · 2012 · 38 citations
    12. IL-36γ drives skin toxicity induced by EGFR/MEK inhibition and commensal Cutibacterium acnes 2019 · 32 citations
    13. Severe skin toxicity during whole-brain radiotherapy, targeted therapy, and additional drug intake including St. John’s wort skin oil Strahlentherapie und Onkologie · 2021 · 9 citations
    14. Non-Rash Skin Toxicities Associated with Novel Targeted Therapies Clinical lung cancer · 2006 · 28 citations
    15. IMMUNE-RELATED SKIN TOXICITIES TO CHECKPOINT INHIBITORS THERAPY Голова и шея. · 2022
    16. The role of dermocosmetics in the management of cancer-related skin toxicities: international expert consensus Supportive Care in Cancer · 2023 · 15 citations
    17. Management of Skin Toxicities in Cancer Treatment: An Australian/New Zealand Perspective Cancers · 2024 · 11 citations
    18. Morphological characteristics and notes of the skin in preclinical toxicity assessment Journal of toxicologic pathology · 2022 · 2 citations
    19. Scientific Opinion on the substantiation of health claims related to soy isoflavones and protection of DNA, proteins and lipids from oxidative damage (ID 1286, 4245), maintenance of normal blood LDL cholesterol concentrations (ID 1135, 1704a, 3093a), reduction of vasomotor symptoms associated with menopause (ID 1654, 1704b, 2140, 3093b, 3154, 3590), maintenance of normal skin tonicity (ID 1704a), contribution to normal hair growth (ID 1704a, 4254), “cardiovascular health” (ID 3587), treatment … EFSA journal · 2011 · 22 citations
    20. Taiwanese Dermatological Association consensus for the prevention and management of epidermal growth factor receptor tyrosine kinase inhibitor-related skin toxicities Journal of the Formosan Medical Association · 2017 · 22 citations
    21. Targeted Therapy– and Chemotherapy-Associated Skin Toxicities: Systematic Review and Meta-Analysis Oncology nursing forum · 2020 · 6 citations
    22. Effect of adenosine triphosphate on ribociclib-induced skin toxicity in rats Cutaneous and Ocular Toxicology · 2023
    23. Scalp Pustule as a Manifestation of Erlotinib-Induced Skin Toxicity: Report of Two Cases and Literature Review Clinical Cosmetic and Investigational Dermatology · 2025 · 1 citations
    24. Protective effects of wheat sprouts extract against acrylamide-induced skin toxicity: Modulation of oxidative stress, apoptosis, and histomorphometric alterations in rats Environmental Science and Pollution Research · 2026
    25. Abemaciclib-Associated Skin, Hair, and Nail Toxicities: A Case Report Curēus · 2024
    26. Understanding, recognizing, and managing toxicities of targeted anticancer therapies Ca · 2013 · 278 citations
    27. Toxic Side Effects of Targeted Therapies and Immunotherapies Affecting the Skin, Oral Mucosa, Hair, and Nails American Journal of Clinical Dermatology · 2018 · 179 citations
    28. Cutaneous toxicity as a predictive biomarker for clinical outcome in patients receiving anticancer therapy Journal of the American Academy of Dermatology · 2018 · 32 citations
    29. Nodular-cystic eruption in course of sorafenib administration for hepatocarcinoma: An unconventional skin reaction requiring unconventional treatment International Journal of Immunopathology and Pharmacology · 2017 · 14 citations
    30. Management of Dermatologic Toxicities Journal of the National Comprehensive Cancer Network · 2015 · 12 citations