When Bugs and Drugs Conspire: Driving Acneiform Skin Toxicity

    February 2020 in “ ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation ”
    Allison C. Billi, Mrinal K. Sarkar, Johann E. Gudjonsson
    Studysummary This study elucidates a mechanism for acne-like skin toxicity caused by EGFR/MEK inhibitors, involving an interaction with skin bacteria to trigger inflammation, which supports existing antibiotic treatment practices.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 5

    1. IL-36γ Drives Skin Toxicity Induced by EGFR/MEK Inhibition and Commensal Cutibacterium Acnes ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2019
    2. EGFR Controls Hair Shaft Differentiation in a p53-Independent Manner iScience · 2019
    3. Brief Report: Requirement of TACE/ADAM17 for Hair Follicle Bulge Niche Establishment Stem Cells · 2012
    4. Tumor Necrosis Factor-Alpha and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice Cancer Research · 2009
    5. Expression of a Dominant Negative Mutant of Epidermal Growth Factor Receptor in the Epidermis of Transgenic Mice Elicits Striking Alterations in Hair Follicle Development and Skin Structure. The EMBO Journal · 1995