EGFR Controls Hair Shaft Differentiation in a p53-Independent Manner

April 2019 in “ iScience ”

Nicole Amberg, Panagiota A. Sotiropoulou, Gerwin Heller, Beate M. Lichtenberger, Martin Holcmann, Bahar Z. Camurdanoglu, Temenuschka Baykuscheva-Gentscheva, Cédric Blanpain, Maria Sibilia

EGFR hair shaft differentiation keratinocytes cell proliferation centrosome function DNA integrity apoptosis hair follicle growth Epidermal Growth Factor Receptor hair growth

TLDR EGFR helps control how hair grows and forms without needing p53 protein.

The study demonstrated that the Epidermal Growth Factor Receptor (EGFR) played a crucial role in hair shaft differentiation independently of the tumor suppressor protein p53. EGFR deficiency in mice led to significant delays in hair follicle growth, structural defects in the hair shaft, and increased DNA damage and apoptosis in keratinocytes. The research highlighted EGFR's importance in regulating cell proliferation, centrosome function, and DNA integrity, suggesting potential therapeutic targets for hair growth and regeneration.

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Research cited in this study

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EGFR Controls Hair Shaft Differentiation in a p53-Independent Manner

Research cited in this study

research Temporal Layering of Signaling Effectors Drives Chromatin Remodeling During Hair Follicle Stem Cell Lineage Progression

research The Epidermal Growth Factor Receptor Decreases Stathmin 1 and Triggers Catagen Entry in the Mouse

research Emerging Interactions Between Skin Stem Cells and Their Niches

research Brief Report: Requirement of TACE/ADAM17 for Hair Follicle Bulge Niche Establishment

research The Basement Membrane Of Hair Follicle Stem Cells Is A Muscle Cell Niche

research Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin

research Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells

research Nfatc1 Balances Quiescence and Proliferation of Skin Stem Cells

research Mice Humanized for the EGF Receptor Display Hypomorphic Phenotypes in Skin, Bone, and Heart

research Tcf3 and Lef1 Regulate Lineage Differentiation of Multipotent Stem Cells in Skin

research Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation

research Conditional Expression of the ErbB2 Oncogene Elicits Reversible Hyperplasia in Stratified Epithelia and Up-Regulation of TGFα Expression in Transgenic Mice

research Severe Follicular Hyperplasia and Spontaneous Papilloma Formation in Transgenic Mice Expressing the Neu Oncogene Under the Control of the Bovine Keratin 5 Promoter

research Genetically Null Mice Reveal a Central Role for Epidermal Growth Factor Receptor in the Differentiation of the Hair Follicle and Normal Hair Development

research Expression of a Dominant Negative Mutant of Epidermal Growth Factor Receptor in the Epidermis of Transgenic Mice Elicits Striking Alterations in Hair Follicle Development and Skin Structure.

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