Hair Growth-Promoting Effect of the Coffee Bean Residue Extract on Hair Follicle Dermal Papilla Cells via the Activation of Autophagy

July 2024 in “ Journal of functional foods ”

Kazunori Sasaki, Aprill Kee Oliva, Hiroko Isoda

coffee bean residue extract ECBR hair follicle dermal papilla cells HFDPCs autophagy ATG2A ATG5 ATG12 ATG14 ATG16L1 VEGFA minoxidil β-catenin/Wnt pathway coffee bean extract hair follicle cells autophagy genes vascular endothelial growth factor A Rogaine Wnt pathway

TLDR Coffee bean residue extract helps hair growth by activating cell processes.

The study found that coffee bean residue extract (ECBR) significantly promotes hair growth in human hair follicle dermal papilla cells (HFDPCs) by enhancing cell viability, ATP production, and the expression of autophagy-related genes (ATG2A, ATG5, ATG12, ATG14, ATG16L1) and VEGFA. Unlike minoxidil, which works through the β-catenin/Wnt pathway, ECBR activates autophagy pathways, suggesting its potential as a novel therapeutic agent for hair loss.

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