3,4,5-Tri-O-Caffeoylquinic Acid Promoted Hair Pigmentation Through β-Catenin and Its Target Genes

    Meriem Bejaoui, Myra O. Villareal, Hiroko Isoda
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    TLDR A substance called TCQA could potentially darken hair by activating certain genes and increasing melanin.
    The study from March 2020 explored the effects of 3,4,5-Tri-O-Caffeoylquinic Acid (TCQA) on hair pigmentation, focusing on its role in activating β-catenin and related pigmentation genes. TCQA was shown to significantly increase melanin content in mouse hair follicles, human melanocytes, and melanoma cells. It upregulated β-catenin expression and pigmentation-associated genes, suggesting its potential as an agent for enhancing hair pigmentation. The study provided evidence that TCQA could stimulate pigmentation during the hair growth cycle by activating β-catenin and increasing melanin biosynthesis. The findings were based on experiments with mouse models and cell lines, indicating a need for clinical studies to confirm TCQA's effectiveness in humans.
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