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research β-catenin-mediated hair growth induction effect of 3,4,5-tri-O-caffeoylquinic acid

42 citations , June 2019 in “Aging”

This study found that treatment with the polyphenolic compound TCQA activated β-catenin, promoting hair regrowth and the initiation of the anagen phase in mice and human dermal papilla cells.

research 3,4,5-Tri-O-Caffeoylquinic Acid Promoted Hair Pigmentation Through β-Catenin and Its Target Genes

13 citations , March 2020 in “Frontiers in cell and developmental biology”

This study suggests that 3,4,5-tri-O-caffeoylquinic acid activates β-catenin to enhance pigmentation in mouse hair follicles, human melanocytes, and melanoma cells during the hair cycle's growth phase.

research 3D Spheroid Human Dermal Papilla Cell as an Effective Model for the Screening of Hair Growth Promoting Compounds: Examples of Minoxidil and 3,4,5-Tri-O-Caffeoylquinic Acid (TCQA)

2 citations , June 2022 in “Cells”

The study found that growing dermal papilla cells in 3D spheroids enhances their activity with hair growth-promoting agents, such as minoxidil and TCQA, compared to traditional 2D cultures.

research 3D Spheroid Human Dermal Papilla Cell as an Effective Model for the Screening of Hair Growth Promoting Compounds: Examples of Minoxidil and 3,4,5-Tri-O-caffeoylquinic acid (TCQA)

July 2022 in “Institutional Repositories DataBase (IRDB)”

3D spheroid cells effectively test hair growth compounds like Minoxidil.

Establishment of 3D Spheroid Human Dermal Papilla Cells as an Effective Model for Hair Growth Screening Compounds Compared with the 2D System: An Example of Minoxidil and 3,4,5-Tri-O-Caffeoylquinic Acid

research Establishment of 3D Spheroid Human Dermal Papilla Cells as an Effective Model for Hair Growth Screening Compounds Compared with the 2D System: An Example of Minoxidil and 3,4,5-Tri-O-caffeoylquinic acid (TCQA)

November 2021 in “Research Square (Research Square)”

This study found that human hair follicle dermal papilla cells grown in a 3D model influenced hair growth and immune pathways more effectively than those grown in a 2D culture.

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community "Clinical efficacy of microneedle combined with 5% Minoxidil solution and finasteride in the treatment of androgenetic alopecia in males"

in Research/Science 64 upvotes 1 year ago

Microneedling combined with 5% Minoxidil and finasteride significantly improves hair growth compared to using Minoxidil or Minoxidil with finasteride alone. The combination treatment is safe and effective, but further research is needed due to small sample size and short study duration.

community My progress after 4-5 months of taking meds

414 upvotes 7 months ago

The user experienced positive hair regrowth after 4-5 months using oral minoxidil (10mg) and finasteride (1mg) without side effects. Concerns were raised about the high dosage of minoxidil and potential long-term health risks.

community Result after 12 months oral finasteride & 8 months oral minoxidil. No side effects.

in Is this regrowth? 233 upvotes 1 year ago

A 45-year-old male has been using oral finasteride for 12 months and oral minoxidil for 8 months to address hair loss, with plans for a hair transplant next year. He reports no side effects and some improvement, but acknowledges a transplant is needed for full restoration.

community I got my bloodwork done... What now?

in Update 6 upvotes 8 months ago

The user has been experiencing hair thinning despite taking finasteride and minoxidil for six months. Bloodwork suggests a vitamin D deficiency, and users recommend consulting a doctor and possibly supplementing vitamin D.

community Is it me or are people losing their hair very young now?

in Finasteride/Dutasteride 143 upvotes 6 years ago

People notice more young individuals experiencing hair loss and discuss possible reasons, such as diet, hormones, and stress. Some treatments mentioned include finasteride, dutasteride, and minoxidil.

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