The Cell Biology of Human Hair Follicle Pigmentation
November 2010
in “
Pigment cell & melanoma research
”
hair follicle pigmentation epidermal-melanin unit hair growth cycle epidermal melanocytes follicular melanocytes vitiligo alopecia areata melanoma follicular melanocyte sub-populations aging hair pigmentation skin pigmentation hair cycle skin melanocytes hair melanocytes skin condition hair loss skin cancer melanocyte groups aging effects
TLDR We need more research on human hair follicle pigmentation, not just mouse models.
The document discussed the limited understanding of human hair follicle pigmentation regulation compared to the better-studied UVR-exposed epidermal-melanin unit. It highlighted the challenges due to gaps in knowledge about the hair growth cycle and the over-reliance on mouse models, which may not accurately represent human conditions. The author emphasized the importance of recognizing the distinct roles of epidermal and follicular melanocytes in human skin, particularly in the context of conditions like vitiligo, alopecia areata, and melanoma. The document called for more research into why hair follicle and epidermal pigmentary units are distinct, why melanomas typically originate from epidermal melanocytes, the existence of multiple follicular melanocyte sub-populations, and the greater sensitivity of follicular melanocytes to aging.
