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Glossary Hair Follicle Pigmentation

process of melanin deposition in hair shaft

Hair follicle pigmentation refers to the process by which melanin, the natural pigment produced by specialized cells called melanocytes, is deposited in the hair shaft within the hair follicle. This pigmentation determines the color of the hair, ranging from black and brown to blonde and red, and can be influenced by genetic factors, hormonal changes, and aging.

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Research

5 / 1000+ results

research Hair Follicle Pigmentation

450 citations , January 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

This article reviews follicular melanogenesis, detailing how melanin synthesis and its regulation in hair follicles depend on a complex interplay of cellular and molecular mechanisms, but reports no new clinical findings.

research The cell biology of human hair follicle pigmentation

127 citations , November 2010 in “Pigment cell & melanoma research”

This article discusses the challenges in hair follicle pigmentation research compared to epidermal melanocytes and highlights the limitations of relying on mouse models, but reports no new experimental findings.

research Aging of the hair follicle pigmentation system

75 citations , January 2009 in “International journal of trichology”

This review examines the differential aging of melanocytes in hair follicles and skin, and reports no new findings; the authors suggest further research is needed to understand these processes.

research Effects of the selective TrkA agonist gambogic amide on pigmentation and growth of human hair follicles in vitro

6 citations , August 2019 in “PLOS ONE”

The researchers reported that Gambogic Amide may prevent hair greying and promote hair growth by maintaining follicle pigmentation in vitro through activation and migration of melanocytes.

research Exosomal miR ‐199a‐3p From Dermal Papilla Cells Regulates Hair Follicle Pigmentation by Targeting POU2F1 in Melanocytes

April 2026 in “The FASEB Journal”

In this study, researchers identified exosomal miR-199a-3p as a key factor in the regulation of melanogenesis by dermal papilla cells, finding that it enhances melanocyte proliferation and melanin production, suggesting potential therapeutic targets for pigmentation disorders.

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Community Join

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community What is this pigmentation around my follicles?

in Chat 29 upvotes 1 year ago

The conversation discusses potential causes of pigmentation around hair follicles, suggesting sebum buildup, autoimmune conditions, or dermatitis. Treatments mentioned include finasteride, dutasteride, and an anti-inflammatory diet, with a recommendation to consult a doctor for a proper diagnosis.

community PP405 Won't Work Long Term: Hair Follicle Damage Due to Abuse of the ISR System

67 upvotes 11 months ago

PP405 may damage hair follicles if used long-term, suggesting cycling might be necessary. Combining it with finasteride could help maintain hair growth.

community What Are the Technicalities of Curved Hair Transplantation?

4 upvotes 5 months ago

Curved hair transplantation requires specialized tools and techniques to avoid damaging hair follicles, with modified FUE being the preferred method. Proper extraction and implantation angles are crucial to prevent complications like keloids and sterile folliculitis.

community My donor hair is still red after a year and a half.

58 upvotes 2 months ago

The conversation is about a user experiencing redness and tingling in the donor area after a hair transplant, with suggestions to use treatments like dutasteride and minoxidil. Other users recommend consulting a doctor, considering scalp micro pigmentation, or using body hair for future transplants.

community If we can clone a sheep why we can't cure baldness till now

in Research/Science 181 upvotes 1 year ago

Hair loss treatments like Minoxidil, finasteride, and stem cell therapies exist, but a complete cure is hindered by genetic complexity and market dynamics. Cloning hair follicles is considered a potential solution, but it's currently not feasible.

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Learn

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learn Scalp Micropigmentation

Will scalp micropigmentation damage my existing hair or follicles? Scalp micropigmentation does not damage existing hair or follicles.
Will scalp micropigmentation grow my hair back? Scalp micropigmentation does not grow hair back; it only enhances appearance.
Does scalp micropigmentation look natural? Scalp micropigmentation can look natural if performed by a skilled practitioner.
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learn Latanoprost

glaucoma medication with hair follicle stimulant effects

learn Hair Multiplication

extract, clone, and reinsert your own hair cells

learn Rapamycin

mTOR regulator and immunosuppressant used more recently for anti-aging and hair regrowth

learn Overview

learn Stem Cell Factor

learn Niacinamide

How does Niacinamide support the hair follicle’s nutrition? Niacinamide nourishes hair follicles by boosting energy production and supporting antioxidant defenses.

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Clinics

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Experts

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Unscored
SMP Specialist
Hairo Fallas
Newark, NJ, United States

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Hairo Fallas