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research [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs

26 citations , July 2007 in “Biochemical Pharmacology”

This study found that phenyl-imidazole sulfonamide derivatives, particularly ISCK03, inhibited c-kit signaling and promoted depigmentation in various experimental settings, suggesting potential use as skin-whitening agents.

research Regulatory Effects of Thai Rice By-Product Extracts from Oryza sativa L. cv. Bue Bang 3 CMU and Bue Bang 4 CMU on Melanin Production, Nitric Oxide Secretion, and Steroid 5α-Reductase Inhibition

1 citations , February 2023 in “Plants”

This study reported that rice bran oil from the Thai rice variety BB4CMU showed potential in promoting melanin production and inhibiting steroid 5α-reductase, suggesting a natural option for hair revitalization.

research STIMULATING EFFECT OF ADRENALECTOMY ON HAIR GROWTH AND MELANIN DEPOSITION IN BLACK RATS FED DIETS ADEQUATE AND DEFICIENT IN THE FILTRATE FACTORS OF VITAMIN B¹

34 citations , January 1943 in “Endocrinology”

In this study, adrenalectomy in rats on a diet lacking certain vitamin B components reversed fur graying and enhanced hair growth.

research When the Circadian Clock Meets the Melanin Pigmentary System

18 citations , March 2015 in “Journal of Investigative Dermatology”

In this study, silencing BMAL1 and PER1 genes increased melanogenic activity in follicular and epidermal melanocytes, suggesting that peripheral circadian clocks may regulate melanin pigmentation.

research Epimedium brevicornum Maxim. Extract exhibits pigmentation by melanin biosynthesis and melanosome biogenesis/transfer

6 citations , September 2022 in “Frontiers in pharmacology”

In this study, Epimedii Folium extract was found to enhance melanin production and promote pigmentation through mechanisms involving the MAPK/ERK1/2 pathway in both in vitro and in vivo models.

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community Finasteride stopping me from tanning & turning my beard and eyebrows white?

in Basic Questions 116 upvotes 6 months ago

Finasteride may inhibit melanin production, affecting tanning and causing white hairs in the beard and eyebrows. The user considers switching to oral Dutasteride or topical treatments to address these issues.

community Prevention of age-related beard graying in humans by the topical application of Eriodictyon angustifolium extract

5 upvotes 4 years ago

Topical application of Eriodictyon angustifolium extract can prevent and reverse age-related beard graying and darken gray hair by increasing melanin production. Sterubin, a component of the extract, also promotes hair pigmentation and protects cells from DNA damage.

community Fully functional hair follicle regeneration through the rearrangement of stem cells and their niches

4 upvotes 11 years ago

Hair follicle regeneration through stem cell rearrangement is discussed, focusing on bioengineered cellular structures rather than traditional hair transplants. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community Six Month Progress Update - Hair Darker than Ever

162 upvotes 11 months ago

The user experienced significant hair darkening and progress in hair regrowth over six months using 5% topical minoxidil, 5 mg oral minoxidil, 1 mg finasteride, and weekly microneedling. No side effects were reported from these treatments.

community Progress photos, topical min/fin 1x daily, be consistent and look after your health and stress levels.

in Progress Pictures 278 upvotes 1 year ago

The user shared progress photos of hair regrowth using a topical spray with 0.3% finasteride and 6% minoxidil, applied daily. They experienced significant shedding initially, but hair loss stopped and noticeable regrowth began around 16-18 months, with improved hair color and no side effects.

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