Regulatory Effects of Thai Rice By-Product Extracts from Oryza Sativa L. Cv. Bue Bang 3 CMU and Bue Bang 4 CMU on Melanin Production, Nitric Oxide Secretion, and Steroid 5α-Reductase Inhibition

    February 2023 in “ Plants ”
    Warintorn Ruksiriwanich, Pichchapa Linsaenkart, Chiranan Khantham, Anurak Muangsanguan, Korawan Sringarm, Pensak Jantrawut, Chanakan Prom‐u‐thai, Sansanee Jamjod, Supapohn Yamuangmorn, Chaiwat Arjin, Pornchai Rachtanapun, Kittisak Jantanasakulwong, Yuthana Phimolsiripol, Francisco J. Barba, Sarana Rose Sommano, Romchat Chutoprapat, Korawinwich Boonpisuttinant
    TLDR BB4CMU rice bran oil may help treat hair loss and gray hair.
    The study explored the effects of Thai rice by-product extracts from Oryza sativa L. cv. Bue Bang 3 CMU (BB3CMU) and Bue Bang 4 CMU (BB4CMU) on melanin production, nitric oxide secretion, and steroid 5α-reductase inhibition. BB4CMU rice bran oil (RBO) significantly increased melanin production in melanocytes and nitric oxide levels, while also inhibiting steroid 5α-reductase genes SRD5A1 and SRD5A2, which are linked to hair loss. The extracts demonstrated strong antioxidant properties and were non-cytotoxic to various cell lines, suggesting their safety for scalp application. These findings indicate that BB4CMU-RBO, rich in tocopherols and fatty acids, has high potential for promoting hair growth, re-pigmentation, and treating hair loss with fewer side effects.
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