Fabrication and Characterization of Dissolving Microneedles Containing Oryza Sativa L. Extract Complex for Enhancement of Transfollicular Delivery

August 2024 in “ Polymers ”

Tanpong Chaiwarit, Baramee Chanabodeechalermrung, Pensak Jantrawut, Warintorn Ruksiriwanich, Mathukorn Sainakham

dissolving microneedles Oryza sativa L. extract transfollicular delivery PVP K90 linoleic acid hair follicles keratinocytes rice extract polyvinylpyrrolidone hair follicle delivery

TLDR The P25H5-O microneedles effectively deliver substances through hair follicles and are safe for skin cells.

This study developed dissolving microneedles containing Oryza sativa L. extract complex to enhance transfollicular delivery. The P25H5 formulation, with a high PVP K90 content, showed superior mechanical strength, skin penetration, and dissolution properties. The microneedles effectively delivered linoleic acid through hair follicles, with significant differences in penetration between opened and blocked follicle conditions. The P25H5-O microneedles were identified as the most promising due to their optimal characteristics, including high drug-loading content (92.95%) and safety for keratinocytes, maintaining over 90% cell viability.

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Fabrication and Characterization of Dissolving Microneedles Containing Oryza Sativa L. Extract Complex for Enhancement of Transfollicular Delivery

Research cited in this study

research Regulatory Effects of Thai Rice By-Product Extracts from Oryza Sativa L. Cv. Bue Bang 3 CMU and Bue Bang 4 CMU on Melanin Production, Nitric Oxide Secretion, and Steroid 5α-Reductase Inhibition

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research Nanotechnology-Driven Delivery of Caffeine Using Ultradeformable Liposomes-Coated Hollow Mesoporous Silica Nanoparticles for Enhanced Follicular Delivery and Treatment of Androgenetic Alopecia

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