Fabrication and Characterization of Dissolving Microneedles Containing Oryza Sativa L. Extract Complex for Enhancement of Transfollicular Delivery

August 2024 in “ Polymers ”

Tanpong Chaiwarit, Baramee Chanabodeechalermrung, Pensak Jantrawut, Warintorn Ruksiriwanich, Mathukorn Sainakham

dissolving microneedles Oryza sativa L. extract transfollicular delivery PVP K90 linoleic acid hair follicles keratinocytes rice extract polyvinylpyrrolidone hair follicle delivery

Studysummary This study observed that dissolving microneedles made from PVP-K90 and HPMC E50, incorporating Oryza sativa L. extract complex, showed enhanced transfollicular skin penetration and maintained safety for keratinocytes, with the P25H5 formulation demonstrating faster dissolution and greater effectiveness.

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This study developed dissolving microneedles containing Oryza sativa L. extract complex to enhance transfollicular delivery. The P25H5 formulation, with a high PVP K90 content, showed superior mechanical strength, skin penetration, and dissolution properties. The microneedles effectively delivered linoleic acid through hair follicles, with significant differences in penetration between opened and blocked follicle conditions. The P25H5-O microneedles were identified as the most promising due to their optimal characteristics, including high drug-loading content (92.95%) and safety for keratinocytes, maintaining over 90% cell viability.

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