Activation of Hair Cell Growth Factors by Linoleic Acid in Malva Verticillata Seed

    April 2021 in “ Molecules/Molecules online/Molecules annual ”
    Hwa Sun Ryu, Jeong Ji-Yeon, Chun Mong Lee, Kwang-Sik Lee, Jungno Lee, Sung Min Park, Young Moo Lee
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    TLDR Linoleic acid from Malva verticillata seeds may help treat hair loss by promoting hair cell growth and blocking baldness signals.
    The study from April 7, 2021, demonstrated that linoleic acid (LA) extracted from Malva verticillata seeds significantly promoted hair growth by increasing the proliferation of human follicles dermal papilla cells (HFDPCs) and activating the Wnt/ß-catenin signaling pathway. LA treatment also upregulated the expression of cell cycle proteins and growth factors such as VEGF, IGF-1, HGF, and KGF in a dose-dependent manner. Furthermore, LA inhibited the expression of DKK-1, a molecule associated with alopecia signaling induced by dihydrotestosterone (DHT). These findings suggest that LA could be a potential treatment for hair loss. The experiments were conducted at least three times to ensure the results were reliable.
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