Malva Verticillata Seed Extracts Upregulate the Wnt Pathway in Human Dermal Papilla Cells
August 2015
in “
International Journal of Cosmetic Science
”
Malva verticillata myristoleic acid Wnt pathway β-catenin human dermal papilla cells DPCs IGF-1 KGF VEGF HGF MAPKs Akt p38 Wnt/β-catenin signaling pathway insulin-like growth factor 1 keratinocyte growth factor vascular endothelial growth factor hepatocyte growth factor mitogen-activated protein kinases
TLDR Malva verticillata seed extract might help treat hair loss by activating hair growth signals in skin cells.
The study from 8 years ago demonstrated that Malva verticillata seed extracts, particularly myristoleic acid, could potentially treat hair loss by activating the Wnt/β-catenin signaling pathway in human dermal papilla cells (DPCs). The extract increased Wnt reporter activity and β-catenin levels in a concentration-dependent manner. Myristoleic acid was found to stimulate DPC proliferation and upregulate hair growth-related cytokines such as IGF-1, KGF, VEGF, and HGF. It also promoted the phosphorylation of MAPKs, including Akt and p38. These findings suggest that myristoleic acid from M. verticillata seeds may be a promising candidate for developing hair loss treatments.
