Malva Verticillata Seed Extracts Upregulate the Wnt Pathway in Human Dermal Papilla Cells

August 2015 in “ International Journal of Cosmetic Science ”

E. Y. Lee, Eunju Choi, J. A. Kim, Yumi Hwang, C.-D. Kim, M. H. Lee, Seok Seon Roh, Y. H. Kim, Inbo Han, Sung Soo Kang

Malva verticillata myristoleic acid Wnt pathway β-catenin human dermal papilla cells DPCs IGF-1 KGF VEGF HGF MAPKs Akt p38 Wnt/β-catenin signaling pathway insulin-like growth factor 1 keratinocyte growth factor vascular endothelial growth factor hepatocyte growth factor mitogen-activated protein kinases

Studysummary This study suggests that an extract from Malva verticillata seeds could help treat hair loss by modulating the Wnt/β-catenin pathway in cultured human dermal papilla cells.

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The study from 8 years ago demonstrated that Malva verticillata seed extracts, particularly myristoleic acid, could potentially treat hair loss by activating the Wnt/β-catenin signaling pathway in human dermal papilla cells (DPCs). The extract increased Wnt reporter activity and β-catenin levels in a concentration-dependent manner. Myristoleic acid was found to stimulate DPC proliferation and upregulate hair growth-related cytokines such as IGF-1, KGF, VEGF, and HGF. It also promoted the phosphorylation of MAPKs, including Akt and p38. These findings suggest that myristoleic acid from M. verticillata seeds may be a promising candidate for developing hair loss treatments.

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