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Glossaryp38 MAPK (p38)

enzyme involved in cellular stress and inflammation responses

p38 MAPK, or p38 mitogen-activated protein kinase, is an enzyme that plays a crucial role in cellular responses to stress and inflammation. It is part of a signaling pathway that helps cells react to various external stimuli, such as UV radiation, heat shock, and cytokines, by regulating the expression of specific genes involved in inflammation, cell differentiation, and apoptosis (programmed cell death). This pathway is significant in various biological processes and diseases, including cancer, cardiovascular diseases, and inflammatory conditions.

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Cyanidin 3-O-Arabinoside Suppresses DHT-Induced Dermal Papilla Cell Senescence by Modulating p38-Dependent ER-Mitochondria Contacts

research Cyanidin 3-O-Arabinoside Suppresses DHT-Induced Dermal Papilla Cell Senescence by Modulating p38-Dependent ER-Mitochondria Contacts

14 citations, March 2022 in “Journal of Biomedical Science”

Cyanidin 3-O-arabinoside may help treat a common form of hair loss by protecting cells against aging and improving cell function.

research Jiawei Erzhiwan Ameliorates Androgenetic Alopecia by Regulating the SIRT1/JNK/p38 MAPK Pathway

April 2025 in “Drug Design Development and Therapy”

Jiawei Erzhiwan helps hair growth in androgenetic alopecia by affecting specific cell pathways.

In Vitro Hair Growth-Promoting Effects of Araliadiol via the p38/PPAR-γ Signaling Pathway in Human Hair Follicle Stem Cells and Dermal Papilla Cells

research In Vitro Hair Growth-Promoting Effects of Araliadiol via the p38/PPAR-γ Signaling Pathway in Human Hair Follicle Stem Cells and Dermal Papilla Cells

December 2024 in “Frontiers in Pharmacology”

Araliadiol may promote hair growth like minoxidil without being toxic.

research Kinetics of Titan Cells Generation and Transcriptome Modifications Comparing Three In Vitro Protocols

September 2022 in “Medical Mycology”

Three different methods were compared for creating Titan cells, a type of fungus cell. The OZ method made the most cells initially, but the number dropped quickly. The EB method also made a lot of cells, but the number also dropped. The AA method made fewer cells, but the number stayed steady. The methods also affected which genes were active in the cells.

research Scalp Fungal Microbiome and Sebum Composition in Males With and Without Androgenetic Alopecia

September 2022 in “Medical Mycology”

Scalp fungi and sebum differences may affect hair loss in men.

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community Cell senescence-targeted treatment for hair loss, has anyone tried any products/enzymes etc. that use this theory

in Research/Science 4 upvotes 1 month ago

DHT causes hair loss by driving cells into senescence, and a polyphenol in black chokeberry may reverse this. A product using this theory is being considered for use alongside finasteride, minoxidil, and microneedling.

community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 736 upvotes 2 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community Aronia Chokeberry and Cyanidin 3-O-arabinoside for Hair Growth (AGA) Study

in Research/Science 14 upvotes 1 year ago

A natural compound called C3A from Aronia Chokeberry can help prevent hair loss by counteracting the effects of DHT. The user has been taking 50 grams of dried organic Aronia Chokeberry daily for 30 days and will update with photos in 60 days.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 6 months ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 5 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.