The Androgenic Alopecia Protective Effects of Forsythiaside-A and the Molecular Regulation in a Mouse Model
March 2015
in “
Phytotherapy Research
”
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Studysummary This study found that forsythiaside-A, a natural compound from Forsythia suspensa, was more effective than finasteride at preventing apoptosis of hair cells and delaying the catagen phase entry in an androgenic alopecia mouse model. Our plain-language summary of this paper — not a Tressless recommendation.
In 2015, a study found that Forsythiaside-A, a natural substance, had protective effects against androgenic alopecia (hair loss) in a mouse model. The substance resulted in a 30% greater inhibition of DHT-induced apoptosis in human hair cells compared to finasteride. In vivo experiments showed a 50% increase in mouse hair density and a 30% increase in thickness with Forsythiaside-A treatment compared to a DHT group. The treated group also showed a 60% increase in the Bcl-2/Bax ratio, a factor related to mitochondrial apoptosis. The study concluded that Forsythiaside-A prevents apoptosis similarly to finasteride but is more effective, suggesting its potential as a treatment for androgenic alopecia.
