Evaluation of Androgens in the Scalp Hair and Plasma of Patients with Male-Pattern Baldness Before and After Finasteride Administration

    January 2006 in “ British Journal of Dermatology
    Hoon Ryu, Ki Wook Kim, Eun Ah Yoo, Wonbo Sim, Bow Chung
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    TLDR Finasteride lowers scalp and blood DHT levels, potentially treating male-pattern baldness.
    This study examined the effect of finasteride on androgen levels in the scalp hair and plasma of male-pattern baldness (MPB) patients. The results showed that finasteride significantly decreased the levels of dihydrotestosterone (DHT) in both plasma and vertex scalp hair, while having no effect on testosterone (T) levels. The study suggests that finasteride may be an effective treatment for MPB by reducing the levels of DHT.
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      community Is this broscience? From More Plates, More Dates

      in Research/Science  21 upvotes 2 years ago
      The conversation discusses whether finasteride's reduction of DHT and increase in scalp testosterone contribute to hair follicle miniaturization. Some participants argue testosterone does not cause miniaturization, while others suggest that even with reduced DHT, other androgens like testosterone may still contribute to hair loss.

      community Why I really believe the tension theory is the cause of MPB

      in Research/Science  70 upvotes 4 years ago
      The conversation discusses the tension theory as a cause of male pattern baldness (MPB), suggesting that scalp tension and reduced subcutaneous fat layer contribute to hair loss. Treatments mentioned include Minoxidil, finasteride, microneedling, scalp massages, and Botox.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      by nkrata in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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