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Did you mean Bcl-2/Bax ratio?

Glossary Bcl-2/Bax ratio

balance between cell survival and cell death proteins

The Bcl-2/Bax ratio refers to the balance between two types of proteins that regulate cell death. Bcl-2 is a protein that prevents cells from dying, while Bax promotes cell death. A higher Bcl-2/Bax ratio means cells are more likely to survive, whereas a lower ratio indicates a higher likelihood of cell death. This balance is crucial in processes like cancer development and treatment, as well as in conditions like alopecia where cell survival and death are key factors.

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research Human hair growth enhancement in vitro by green tea epigallocatechin-3-gallate (EGCG)

108 citations , November 2006 in “Phytomedicine”

This study found that EGCG from green tea may stimulate human hair growth by promoting the proliferation and anti-apoptotic activity in dermal papilla cells.

research The Additive Effects of Minoxidil and Retinol on Human Hair Growth in Vitro

32 citations , January 2007 in “Biological & Pharmaceutical Bulletin”

This study found that combining minoxidil and retinol additively promoted hair growth in vitro, enhancing Erk- and Akt-dependent pathways and preventing apoptosis in dermal papilla cells and keratinocytes.

research The Androgenic Alopecia Protective Effects of Forsythiaside-A and the Molecular Regulation in a Mouse Model

26 citations , March 2015 in “Phytotherapy Research”

This study found that forsythiaside-A, a natural compound from Forsythia suspensa, was more effective than finasteride at preventing apoptosis of hair cells and delaying the catagen phase entry in an androgenic alopecia mouse model.

research Hair growth potential of Salvia plebeia extract and its associated mechanisms

21 citations , January 2020 in “Pharmaceutical Biology”

In this study, Salvia plebeia extract promoted hair growth by enhancing proliferation and anti-apoptotic effects in human dermal papilla cells and increased hair growth in treated mice.

research 6-Gingerol Inhibits Hair Shaft Growth in Cultured Human Hair Follicles and Modulates Hair Growth in Mice

17 citations , February 2013 in “PLOS ONE”

This study found that 6-gingerol, a component of ginger, suppresses hair growth rather than promoting it, both in vitro and in vivo, suggesting potential use in hair removal treatments.

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community Prolactin the Cause of Hair Loss? ABS-201 the Cure?

29 upvotes 2 months ago

Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.

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