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GlossaryBcl-2 family

regulates cell death and survival through protein interactions

The Bcl-2 family, also known as the B-cell lymphoma 2 family, is a group of proteins that play a crucial role in regulating cell death (apoptosis). These proteins can either promote survival or trigger cell death, and their balance is essential for maintaining healthy tissue function and preventing diseases like cancer.

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research Protein Kinase Akt2/PKBβ Is Involved in Blastomere Proliferation of Preimplantation Mouse Embryos

7 citations , September 2019 in “Journal of Cellular Physiology”

Akt2 protein is essential for normal cell division in early mouse embryos.

research Synthesized Ceramide Induces Growth of Dermal Papilla Cells with Potential Contribution to Hair Growth

7 citations , January 2019 in “Annals of dermatology/Annals of Dermatology”

Synthetic ceramides may help hair growth by boosting cell growth in hair follicles.

Overexpression of Bcl-2 Protects from Ultraviolet B-Induced Apoptosis but Promotes Hair Follicle Regression and Chemotherapy-Induced Alopecia

research Overexpression of Bcl-2 Protects from Ultraviolet B-Induced Apoptosis but Promotes Hair Follicle Regression and Chemotherapy-Induced Alopecia

47 citations , April 2000 in “The American journal of pathology”

Bcl-2 overexpression protects against UVB damage but worsens hair loss from chemotherapy.

A Medicinal and Edible Formula YH0618 Ameliorates the Toxicity Induced by Doxorubicin via Regulating the Expression of Bax/Bcl-2 and FOXO4

research A Medicinal and Edible Formula YH0618 Ameliorates the Toxicity Induced by Doxorubicin via Regulating the Expression of Bax/Bcl-2 and FOXO4

17 citations , January 2019 in “Journal of cancer”

The formula YH0618 can reduce the harmful side effects of the chemotherapy drug Doxorubicin and protect healthy cells.

research Hydroxyl Radical Mediates Cisplatin-Induced Apoptosis in Human Hair Follicle Dermal Papilla Cells and Keratinocytes Through Bcl-2-Dependent Mechanism

52 citations , May 2011 in “APOPTOSIS”

Hydroxyl radicals cause hair follicle cell death during chemotherapy by reducing Bcl-2 protein levels.

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community The end of balding: We may have just found the secret to hair regrowth

in Technology 676 upvotes 5 months ago

MCL-1 is important for hair follicle stem cell survival, but its impact on human hair regrowth is unclear. Minoxidil and finasteride are the main treatments, with doubts about new discoveries leading to effective human solutions soon.