Canonical Wnt-10b Signaling Exerts an Ability to Maintain Mouse Dermal Papilla Cells

    September 2016 in “ Journal of Dermatological Science ”
    Yukiteru Ouji, Fkumi Nakamura-Uchiyama, Masahide Yoshikawa
    Image of study
    TLDR Wnt-10b is important for keeping mouse skin cells healthy for hair growth.
    The document presents findings from a study on the role of canonical Wnt-10b signaling in maintaining mouse dermal papilla (DP) cells, which are crucial for hair follicle development and cycling. DP cells from 4-week-old C3H/HeN mice were cultured with various Wnts (Wnt-3a, Wnt-5a, Wnt-10b, and Wnt-11), and it was found that only Wnt-10b significantly promoted the proliferation of DP cells and maintained their hair induction ability, as evidenced by positive alkaline phosphatase (ALP) staining and successful hair follicle formation and hair growth induction upon co-transplantation with epithelial cells. In contrast, Wnt-3a showed limited maintenance, while Wnt-5a and Wnt-11 had no effect. The study concludes that Wnt-10b plays a crucial role in the maintenance of DP cells and hair formation.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 123 results

      community Better Than Minoxidil? Topical Sodium Valproate

      in Research/Science  52 upvotes 1 year ago
      Topical sodium valproate may promote hair growth by inhibiting GSK3β, allowing beta-catenin to proliferate, but it has potential side effects and requires more research. The conversation also mentions skepticism about a product called Vdphlo1, which includes sodium valproate and other ingredients.

      community Natural Remedies: Polyphenols and Hair Loss

       20 upvotes 6 years ago
      Natural remedies to treat hair loss, such as polyphenols, apple peel extract, grape seed extract, green tea extract, peppermint oil, pumpkin seed oil, apigenin, Ginkgo biloba, red clover extract, olive leaf extract, Ecklonia Cava and Grateloupia elliptica. In addition, terpenes, carotenoids, and tocopherols were discussed as potential treatments.

      community A Theory on Why Microneedling Works

       170 upvotes 6 years ago
      Microneedling may enhance hair regrowth by transferring stem cells to dormant follicles, improving the effects of minoxidil. Users discuss using microneedling with needle lengths around 1.5mm to stimulate hair growth.

      community Do you keep gains if you stop microneedling?

      in Microneedling  15 upvotes 7 months ago
      Stopping microneedling may result in losing hair gains, as it enhances the effectiveness of treatments like minoxidil. Combining microneedling with minoxidil and finasteride is more effective than using microneedling alone.

    Related Research

    6 / 6 results