Canonical Wnt-10b Signaling Exerts an Ability to Maintain Mouse Dermal Papilla Cells

September 2016 in “ Journal of Dermatological Science ”

Yukiteru Ouji, Fkumi Nakamura-Uchiyama, Masahide Yoshikawa

Wnt-10b dermal papilla cells hair follicle development hair cycling Wnt-3a Wnt-5a Wnt-11 alkaline phosphatase staining hair induction epithelial cells hair growth induction DP cells hair growth hair formation

TLDR Wnt-10b is important for keeping mouse skin cells healthy for hair growth.

The document presents findings from a study on the role of canonical Wnt-10b signaling in maintaining mouse dermal papilla (DP) cells, which are crucial for hair follicle development and cycling. DP cells from 4-week-old C3H/HeN mice were cultured with various Wnts (Wnt-3a, Wnt-5a, Wnt-10b, and Wnt-11), and it was found that only Wnt-10b significantly promoted the proliferation of DP cells and maintained their hair induction ability, as evidenced by positive alkaline phosphatase (ALP) staining and successful hair follicle formation and hair growth induction upon co-transplantation with epithelial cells. In contrast, Wnt-3a showed limited maintenance, while Wnt-5a and Wnt-11 had no effect. The study concludes that Wnt-10b plays a crucial role in the maintenance of DP cells and hair formation.

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