miR-195-5p Regulates Hair Follicle Inductivity of Dermal Papilla Cells by Suppressing Wnt/β-Catenin Activation

    January 2018 in “ BioMed Research International ”
    Ningxia Zhu, Keng Huang, Yang Liu, Huan Zhang, Emily Lin, Yang Zeng, Haihong Li, Yan‐Ming Xu, Bin Cai, Yanping Yuan, Yu Liu, Cheng Huang Lin
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    Studysummary This study suggests that miRNAs, particularly miR-195-5p, may regulate the loss of hair follicle inductivity in cultured dermal papilla cells by suppressing the Wnt/β-catenin pathway. Our plain-language summary of this paper — not a Tressless recommendation.
    In the 2018 study, researchers explored the impact of miR-195-5p on the hair follicle inductivity of dermal papilla (DP) cells, particularly its role in the Wnt/β-catenin signaling pathway. They discovered that miR-195-5p was more abundant in late-passage DP cells, which lack the ability to induce hair follicle development, and less abundant in early-passage DP cells, which retain this inductive capacity. Overexpression of miR-195-5p resulted in a dose-dependent reduction of β-catenin expression and decreased levels of LRP6 and other genes involved in hair follicle inductivity. The study concluded that miR-195-5p suppresses Wnt/β-catenin signaling, which may lead to the loss of hair follicle inductivity in DP cells. The findings provide potential targets for maintaining or restoring the hair-inducing capacity of DP cells and were supported by data available in the Gene Expression Omnibus under accession number GSE77825.
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