Androgens Modify Wnt Agonists/Antagonists Expression Balance in Dermal Papilla Cells Preventing Hair Follicle Stem Cell Differentiation in Androgenetic Alopecia

    October 2016 in “ Molecular and Cellular Endocrinology ”
    Gustavo José Leirós, Julieta M. Ceruti, Maria Clara Castellanos, Ana Gabriela Kusinsky, María Eugenia Balañá
    Image of study
    TLDR Androgens prevent hair growth by changing Wnt signals in cells.
    This study from 2017 found that androgens, specifically DHT, can prevent hair follicle stem cell differentiation in androgenetic alopecia by modifying the balance of Wnt agonists/antagonists expression in dermal papilla cells. The study suggests that targeting the Wnt signaling pathway may be a potential therapeutic approach for AGA. The researchers found that androgens upregulated the expression of the Wnt-ligand antagonist Dkk-1 in DPC, while downregulating the expression of the Wnt agonists Wnt10b and Wnt5a. The study also found that DKK-1 could block the inductive action of DPC on HFSC differentiation, mimicking the effect of androgens.
    Discuss this study in the Community →

    Research cited in this study

    15 / 15 results

    Related Community Posts Join

    6 / 1000+ results

      community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

      in Research/Science  92 upvotes 2 years ago
      The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 2 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

    Related Research

    5 / 5 results