Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia

May 2012 in “ British Journal of Dermatology ”

Gustavo José Leirós, Alejandra Inés Attorresi, María Eugenia Balañá

hair follicle stem cell differentiation Wnt/β-catenin androgen signaling dermal papilla cells androgenetic alopecia secreted factors canonical Wnt signaling pathway glycogen synthase kinase-3 GSK-3 Wnt signaling Wnt signaling pathway

TLDR Androgens block hair growth by disrupting cell signals; targeting GSK-3 may help treat hair loss.

The study found that androgens inhibit hair follicle stem cell differentiation through cross-talk between Wnt/β-catenin and androgen signaling in dermal papilla cells from patients with androgenetic alopecia. This is due to the deregulation of secreted factors involved in normal hair follicle stem cell differentiation via the inhibition of the canonical Wnt signaling pathway. The study suggests that inhibiting glycogen synthase kinase-3 (GSK-3) may be a potential therapeutic target for treating androgenetic alopecia.

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