Dermal Papilla-Induced Hair Differentiation of Adult Epithelial Stem Cells from Human Skin

August 2004 in “ Physiological Genomics ”

Cecilia Roh, Qingfeng Tao, Stephen Lyle

TLDR Dermal papilla cells help skin stem cells grow into hair.

The study investigated the interactions between keratinocyte stem cells and dermal papilla (DP) cells, which were essential for hair follicle development and cycling. Using a coculture system, researchers incubated human hair follicle keratinocyte stem cells with DP cells and analyzed gene expression changes over 5 days. They found that several signaling pathways and growth factors were regulated, with the hair-specific keratin 6hf (K6hf) gene showing a 7.9-fold increase in mRNA, indicating its role as a marker of hair differentiation. The study also demonstrated that β-catenin/lef-1 signaling was necessary for DP-induced hair differentiation, highlighting its importance in hair follicle development.

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