Wnt-10b Promotes Differentiation of Skin Epithelial Cells In Vitro

    February 2006 in “ Biochemical and Biophysical Research Communications ”
    Yukiteru Ouji, Masahide Yoshikawa, Akira Shiroi, Shigeaki Ishizaka
    TLDR Wnt-10b helps skin cells develop into hair-related structures.
    The study investigated the role of Wnt-10b in skin epithelial cell differentiation in vitro. Researchers constructed a plasmid carrying the Wnt-10b cDNA gene and introduced it into COS-7 cells to produce recombinant Wnt-10b (rWnt-10b) protein. The study found that Wnt-10b promoted the differentiation of skin epithelial cells, which exhibited characteristics of the hair shaft and inner root sheath of hair follicles. This suggested that Wnt-10b might play a significant role in hair follicle development and regeneration, as its expression was upregulated during the onset of follicle morphogenesis and in postnatal hair follicles beginning a new cycle of hair growth.
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