ES Cell Differentiation Into The Hair Follicle Lineage In Vitro

The study developed an in vitro culture system using the R1 embryonic stem (ES) cell line to differentiate ES cells into mature hair follicle cells expressing hair keratin. This system aimed to address the lack of understanding of the regulatory steps in hair follicle formation, including the identity of stem cells and the signals involved in their differentiation into hair follicle cells. The research suggested that this model could be instrumental in uncovering the mechanisms of hair follicle formation, potentially leading to new treatments for hair growth and regeneration.