A Review of Adipocyte Lineage Cells and Dermal Papilla Cells in Hair Follicle Regeneration

    October 2014 in “ Journal of Tissue Engineering
    Peipei Zhang, Russell E. Kling, Sudheer Ravuri, Lauren E. Kokai, J. Peter Rubin, Jia-ke Chai, Kacey G. Marra
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    TLDR Cell-based therapies using dermal papilla cells and adipocyte lineage cells show potential for hair regeneration.
    This 2014 review article discusses the potential of cell-based therapies for hair regeneration, focusing on the role of dermal papilla cells (DPCs) and adipocyte lineage cells. DPCs are essential for hair follicle growth and regeneration, and adipocyte lineage cells have been reported to participate in the regulation of hair follicle growth. Adipose-derived stem cells (ASCs) show positive effects on DPCs hair-inducing ability, but further work needs to be completed before clinical applications of ASC-based therapeutic approaches in hair regeneration become a clinical reality. The review highlights the importance of intercellular communication and environmental regulation in hair follicle homeostasis.
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