TGF-β2 Is Specifically Expressed in Human Dermal Papilla Cells and Modulates Hair Folliculogenesis

March 2009 in “ Journal of Cellular and Molecular Medicine ”

Keita Inoue, Noriyuki Aoi, Yuji Yamauchi, Takahiro Sato, Hirotaka Suga, Hikaru Eto, Harunosuke Kato, Yasuhiko Tabata, Kotaro Yoshimura

TLDR TGF-β2 plays a key role in human hair growth and development.

In the 2009 study, researchers investigated the role of transforming growth factor (TGF)-β2 in human hair follicle development. They discovered that TGF-β2 was highly expressed in cultured human dermal papilla cells (hDPCs) compared to human dermal fibroblasts. The study also found that keratinocyte conditioned medium increased TGF-β2 expression and alkaline phosphatase (ALP) activity in hDPCs, with ALP being an indicator of the cells' hair-inducing capacity. Additionally, a vitamin D3 analogue was identified as a promoter of TGF-β2 expression and ALP activity in hDPCs. In animal models, blocking TGF-β2 signaling hindered hair follicle formation and maturation, indicating TGF-β2's significant role in hair folliculogenesis. These findings suggest potential strategies for developing cell therapies for hair regrowth involving the transplantation of expanded DPCs. The specific number of participants or cells used in the study was not mentioned in the summary provided.

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Research cited in this study

research Neuroendocrinology of Epithelial Hair Follicle Stem Cells

research Adenosine Stimulates Fibroblast Growth Factor-7 Gene Expression Via Adenosine A2b Receptor Signaling in Dermal Papilla Cells

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research Differences in Expression of Specific Biomarkers Distinguish Human Beard from Scalp Dermal Papilla Cells

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research Different Gene Expression Profile Observed in Dermal Papilla Cells Related to Androgenic Alopecia by DNA Macroarray Analysis

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research Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth

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