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Glossary Alkaline Phosphatase

enzyme that breaks down proteins in various body tissues

Alkaline Phosphatase (ALP) is an enzyme found in various tissues throughout the body, including the liver, bones, kidneys, and digestive system. It plays a crucial role in breaking down proteins and is often measured in blood tests to help diagnose liver disease, bone disorders, and other conditions. Elevated or decreased levels of ALP can indicate issues such as liver damage, bone growth abnormalities, or bile duct obstructions.

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Research

5 / 1000+ results

research Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells

85 citations , April 2012 in “PLOS ONE”

This study found that valproic acid promoted hair re-growth in C3H mice by activating the Wnt/β-catenin pathway, suggesting its potential as a treatment for alopecia.

research Alkaline Phosphatase in Alopecia Areata

23 citations , September 1957 in “Archives of Dermatology”

This study investigated alkaline phosphatase activity in scalp biopsies from patients with alopecia areata and totalis, but provides no new conclusive clinical results.

research Overexpression of alkaline phosphatase improves the hair-inductive capacity of cultured human dermal papilla spheres

13 citations , July 2019 in “Journal of Dermatological Science”

This study suggests that 3D spheroid cultivation of dermal papilla cells can restore their hair-inductive capabilities, which are lost in 2D-cultured cells.

Effects of the Anti-Androgen Finasteride on 5α-Reduction of Androgens in the Presence of Progesterone in Human Gingival Fibroblasts: Modulatory Actions of the Alkaline Phosphatase Inhibitor Levamisole

research Effects of the anti-androgen finasteride on 5α-reduction of androgens in the presence of progesterone in human gingival fibroblasts: modulatory actions of the alkaline phosphatase inhibitor levamisole

9 citations , August 2000 in “Journal of Periodontal Research”

Finasteride reduces testosterone conversion, progesterone lessens this, and levamisole enhances finasteride's effect.

research Proteomics demonstration that histone H4 is a colchicine-induced retro-modulator of growth and alkaline phosphatase activity in hair follicle dermal papilla culture

5 citations , March 2011 in “Journal of proteomics”

This study found that exposing dermal papilla cells to sub-lethal doses of colchicine releases histone H4, which inhibits cell growth and decreases alkaline phosphatase activity, potentially explaining colchicine-induced hair loss.

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Community Join

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community What should I include in my blood test?

in Treatment 1 upvotes 10 months ago

The user has been using finasteride, dutasteride, and minoxidil without success and is considering a comprehensive blood test to explore other causes of hair loss. They are unsure about the necessity and cost of the extensive tests and are seeking advice on whether to proceed with the full panel or focus on specific tests.

community Blood work, is it worth to pay for it?

in Treatment 6 upvotes 10 months ago

The user is considering getting blood work to investigate the cause of ongoing hair loss despite using finasteride and dutasteride. Others suggest that while blood tests can provide useful health information, they may not change the hair treatment outcome.

community What are your thoughts on pre-finasteride blood work?

1 upvotes 3 years ago

The user is considering resuming finasteride after a 6-month break and is debating the necessity of extensive blood work, including hormone and health markers, to establish a baseline. They are unsure if the tests are necessary since they experienced no side effects previously.

community I (23M) want to stop my hair loss and I have a couple questions

3 upvotes 3 years ago

A 23-year-old male is experiencing aggressive hair loss and is considering using finasteride and minoxidil. He is seeking advice on whether to consult a dermatologist for seborrheic dermatitis, the necessity of various medical tests, and the cost of the treatment.

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learn Valproic acid

an anticonvulsant repurposed for hair loss via histone inhibition

learn KY19382

compound that activates Wnt/β-catenin to promote hair regrowth and create new hair follicles

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