Proteomics Demonstration That Histone H4 Is a Colchicine-Induced Retro-Modulator of Growth and Alkaline Phosphatase Activity in Hair Follicle Dermal Papilla Culture

March 2011 in “ Journal of proteomics ”

Ching Wu Hsia, Hao‐Ai Shui, Chih‐Yuan Wang, Hui Ming Yu, M. Ho, Kur Ta Cheng, Min Tseng

colchicine microtubule-disrupting agent alkaline phosphatase dermal papilla cells hair follicles histone H4 proteomic analysis Western blot hair loss drug-induced hair disorders

TLDR Histone H4, released by cells exposed to colchicine, can cause hair loss by inhibiting cell growth and enzyme activity.

The study demonstrated that colchicine, a microtubule-disrupting agent, inhibited the proliferation and reduced the alkaline phosphatase (ALP) activity of dermal papilla cells (DPCs) in hair follicles by inducing the release of histone H4. Histone H4 was identified as the retro-modulator responsible for these effects through proteomic analysis and was validated by Western blot. The findings suggested that histone H4 played a significant role in the mechanism of colchicine-induced hair loss, providing insights into drug-induced hair disorders.

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