Overexpression of Alkaline Phosphatase Improves the Hair-Inductive Capacity of Cultured Human Dermal Papilla Spheres

September 2019 in “ Journal of Dermatological Science ”

Mi Hee Kwack, Yun Jung Jang, Gong Hee Won, Moon Kyu Kim, Jung Chul Kim, Young Kwan Sung

alkaline phosphatase ALPL dermal papilla cells hair-inductive capacity hair growth Wnt/ß-catenin signaling pathway hair follicles genetic modification epidermal cells DP cells Wnt signaling

TLDR Increasing alkaline phosphatase in human skin cells helps to grow more hair.

The study from September 2019 found that overexpressing alkaline phosphatase (ALPL) in human dermal papilla (DP) cells enhances their ability to induce hair growth. DP cells from non-balding individuals were genetically modified to overexpress ALPL, formed into spheres, and implanted into mice along with mouse epidermal cells. The ALPL-modified DP spheres generated significantly more hair follicles (43.3±12.3) than the control group (13.5±8.8). Additionally, the overexpression of ALPL was shown to activate the Wnt/ß-catenin signaling pathway, which is crucial for maintaining the hair-inducing properties of DP cells. These results indicate that ALPL is important for hair follicle induction and suggest a potential new approach for treating hair loss by increasing ALPL expression in DP cells.

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