TLDR Increasing alkaline phosphatase in human skin cells helps to grow more hair.
The study from September 2019 found that overexpressing alkaline phosphatase (ALPL) in human dermal papilla (DP) cells enhances their ability to induce hair growth. DP cells from non-balding individuals were genetically modified to overexpress ALPL, formed into spheres, and implanted into mice along with mouse epidermal cells. The ALPL-modified DP spheres generated significantly more hair follicles (43.3±12.3) than the control group (13.5±8.8). Additionally, the overexpression of ALPL was shown to activate the Wnt/ß-catenin signaling pathway, which is crucial for maintaining the hair-inducing properties of DP cells. These results indicate that ALPL is important for hair follicle induction and suggest a potential new approach for treating hair loss by increasing ALPL expression in DP cells.
256 citations,
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75 citations,
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321 citations,
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208 citations,
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76 citations,
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