Hair Growth-Promoting Effect of Resveratrol in Mice, Human Hair Follicles, and Dermal Papilla Cells

The study investigated the effects of resveratrol (RSV) on hair growth using in vivo, ex vivo, and in vitro models. In C57BL/6 mice, topical application of RSV significantly promoted hair growth by stimulating the transition of the hair cycle from the telogen to the anagen phase. Ex vivo experiments with human hair follicles showed that RSV increased hair shaft length and delayed the transition to the catagen phase. Additionally, in vitro studies demonstrated that RSV enhanced the proliferation of human dermal papilla cells (hDPCs) and protected them from oxidative damage induced by H2O2. These findings suggested that RSV could be a potential candidate for treating hair loss.