Tetrathiomolybdate Decreases the Expression of Alkaline Phosphatase in Dermal Papilla Cells by Increasing Mitochondrial ROS Production

    February 2023 in “ International journal of molecular sciences ”
    Li Fan, Hongli Liu, Xiaojing Wu … Fuchang Li
    Studysummary This study identified that copper depletion in dermal papilla cells reduced hair growth by boosting ROS levels, but ROS scavengers like NAC and ascorbic acid partially alleviated this effect.
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    Research cited in this study 8

    1. Copper Modulates Mitochondrial Oxidative Phosphorylation to Enhance Dermal Papilla Cell Proliferation in Rex Rabbits International Journal of Molecular Sciences · 2022
    2. Dermal Papilla Cells and Melanocytes Response to Physiological Oxygen Levels Depends on Their Interactions Cell Proliferation · 2021
    3. Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle Cell Metabolism · 2020
    4. Hoxc-Dependent Mesenchymal Niche Heterogeneity Drives Regional Hair Follicle Regeneration Cell Stem Cell · 2018
    5. mTOR Signaling Promotes Stem Cell Activation via Counterbalancing BMP-Mediated Suppression During Hair Regeneration Journal of molecular cell biology/Journal of Molecular Cell Biology · 2015
    6. Shh Maintains Dermal Papilla Identity and Hair Morphogenesis via a Noggin–Shh Regulatory Loop Genes & Development · 2012
    7. The Mesenchymal Component of Hair Follicle Neogenesis: Background, Methods, and Molecular Characterization Experimental Dermatology · 2009
    8. The Effect of Tripeptide-Copper Complex on Human Hair Growth In Vitro Archives of Pharmacal Research · 2007