Tetrathiomolybdate Decreases the Expression of Alkaline Phosphatase in Dermal Papilla Cells by Increasing Mitochondrial ROS Production
February 2023
in “
International journal of molecular sciences
”
TLDR Tetrathiomolybdate reduces hair growth marker in skin cells by boosting harmful oxygen molecules, but effects can be reversed.
The study found that tetrathiomolybdate (TM), a copper inactivator, decreases the expression of Alkaline Phosphatase (ALP), a key marker of hair growth, in Dermal Papilla Cells (DPCs) by increasing mitochondrial Reactive Oxygen Species (ROS) production. This leads to a decrease in ATP production and increased total cellular ROS levels, impairing DPC function. However, these effects were reversible within 48 hours of removing TM, and copper supplementation could potentially counteract these effects. The study also found that copper plays a crucial role in hair growth, and its depletion can severely compromise the capacity of DPCs to induce and support hair growth. The study involved multiple tests and measurements, with each group containing between 3 to 8 samples.
