Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle

    September 2020 in “ Cell Metabolism ”
    Christine S. Kim, Xiaolei Ding, Kira Allmeroth … Sara A. Wickström
    Studysummary This study highlights that the mammalian target of rapamycin complex 2 (mTORC2)-Akt signaling axis is essential for hair follicle stem cells to return to their niche and regenerate effectively by regulating metabolic pathways.
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    Research cited in this study 10

    1. Epidermal Mammalian Target of Rapamycin Complex 2 Controls Lipid Synthesis and Filaggrin Processing in Epidermal Barrier Formation Journal of Allergy and Clinical Immunology · 2019
    2. Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations During Wound Healing Cell Reports · 2018
    3. Signaling in the Stem Cell Niche: Regulating Cell Fate, Function, and Plasticity Development · 2018
    4. Topical Inhibition of the Electron Transport Chain Can Stimulate the Hair Cycle Journal of Investigative Dermatology · 2017
    5. Lactate Dehydrogenase Activity Drives Hair Follicle Stem Cell Activation Nature cell biology · 2017
    6. Hair Follicle Stem Cell Cultures Reveal Self-Organizing Plasticity of Stem Cells and Their Progeny The EMBO Journal · 2016
    7. Hair Follicle and Interfollicular Epidermal Stem Cells Make Varying Contributions to Wound Regeneration Cell Cycle · 2015
    8. Emerging Interactions Between Skin Stem Cells and Their Niches Nature Medicine · 2014
    9. Plasticity of Epithelial Stem Cells in Tissue Regeneration Science · 2014
    10. From Telogen to Exogen: Mechanisms Underlying Formation and Subsequent Loss of the Hair Club Fiber Journal of Investigative Dermatology · 2009