Topical Inhibition of the Electron Transport Chain Can Stimulate the Hair Cycle

    October 2017 in “ Journal of Investigative Dermatology ”
    Matilde Miranda, Heather R. Christofk, D. Leanne Jones, William E. Lowry
    Image of study
    TLDR Applying certain inhibitors to the skin can promote hair growth without harming cells.
    The study by Miranda, Christofk, Jones, and Lowry demonstrated that topical application of electron transport chain (ETC) inhibitors (Phenformin, Rotenone, and Antimycin A) on mice can stimulate hair cycle activation, as evidenced by visible pigmentation and hair growth, without causing significant cell toxicity. Histological analysis confirmed a normal transition from the resting phase (telogen) to the growth phase (anagen) in hair follicles, and increased lactate production was observed, which is known to promote hair cycle activation. The treatment was also effective in aged mice, suggesting its potential for treating hair loss. The study involved 13 vehicle-treated and 9 Phenformin-treated male mice, and statistical significance was determined using a student's t-test with P < 0.05.
    Discuss this study in the Community →

    Research cited in this study

    7 / 7 results

    Related Community Posts Join

    6 / 23 results

      community Possible natural pp405 solution

      in Research/Science  45 upvotes 2 months ago
      Rotenone, a natural plant extract, may promote hair growth by increasing LDH activity and blocking MPC in the scalp, but it carries risks due to its toxicity. The suggested formulation includes Barbasco extract, DMSO, propylene glycol or PEG-400, ethanol, and a carrier oil.

      community The mechanism of androgenic alopecia

      in Research/Science  33 upvotes 1 month ago
      DHT may inhibit hair growth by affecting mitochondrial function, leading to hair follicle miniaturization. Treatments like minoxidil and PP405 may promote hair growth by altering metabolic pathways, potentially counteracting DHT's effects.

      community Verteporfin and Microneedling

      in Treatments 1 year ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

      community Should I dedicate my university studies to solving hair loss?

      in Research/Science  373 upvotes 2 years ago
      A 20 year old male who is balding and considering switching to a biology/chemistry program in order to find a low-cost, accessible solution for hair loss. Replies discuss the merits of this idea as well as potential treatments such as Minoxidil, finasteride, RU58841, TM5614, and ADQ.

    Related Research

    7 / 7 results