The Role of Neprilysin in Regulating the Hair Cycle

    February 2013 in “ PLoS ONE ”
    Naoko Morisaki, Atsushi Ohuchi, Shigeru Moriwaki
    Studysummary This study found that neprilysin (NEP) activity and expression play a significant role in regulating the hair cycle in rats, with a specific inhibitor suppressing hair growth in mice.
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    Research cited in this study 10

    1. Regulation Mechanisms of Hair Growth Current problems in dermatology · 2015
    2. CD10 and CD34 in Fetal and Adult Human Hair Follicles: Dynamic Changes in Their Immunohistochemical Expression During Embryogenesis and Hair Cycling British Journal of Dermatology · 2008
    3. Stress Inhibits Hair Growth in Mice by Inducing Premature Catagen Development and Harmful Perifollicular Inflammatory Events via Neuropeptide Substance P-Dependent Pathways American Journal of Pathology · 2003
    4. Ornithine Decarboxylase Transgenic Mice as a Model for Human Atrichia with Papular Lesions Experimental dermatology · 2000
    5. Hair Cycle-Dependent Expression of Hepatocyte Growth Factor Activator, Other Proteinases, and Proteinase Inhibitors Correlates with the Expression of Hepatocyte Growth Factor in Rat Hair Follicles Journal of Investigative Dermatology Symposium Proceedings · 1999
    6. Message of Nexin 1, a Serine Protease Inhibitor, Accumulates in the Follicular Papilla During Anagen of the Hair Cycle Journal of Cell Science · 1995
    7. Use of Gamma-Glutamyl Transpeptidase Activity as a Marker of Hair Cycle and Anagen Induction in Mouse Hair Follicles Journal of Investigative Dermatology · 1994
    8. Regulation of Hair Follicle Development: An In Vitro Model for Hair Follicle Invasion of Dermis and Associated Connective Tissue Remodeling Journal of Investigative Dermatology · 1993
    9. Soluble and Insoluble Collagen and Elastin in the Rat Hair Cycle Archives of Dermatological Research · 1979
    10. Cutaneous Hydroxysteroid Dehydrogenases and Rat Hair Cycle Archives of Dermatological Research · 1975

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