CD10 and CD34 in Fetal and Adult Human Hair Follicles: Dynamic Changes in Their Immunohistochemical Expression During Embryogenesis and Hair Cycling
July 2008
in “
British Journal of Dermatology
”
CD10 CD34 hair follicles embryogenesis hair cycle placode cells matrix cells inner root sheath dermal sheath dermal condensate mesenchymal cells external root sheath anagen follicles catagen phase telogen phase hair follicle morphogenesis hair regeneration hair loss therapies hair growth cycle hair growth phases hair follicle development hair loss treatment
TLDR CD10 and CD34 levels change during hair development and different hair growth stages, which could be important for hair regeneration treatments.
The 2008 study investigated the expression of CD10 and CD34 in human hair follicles during embryogenesis and the hair cycle. It was found that CD10 and CD34 expression is dynamic and varies with the stage of hair follicle development and the hair cycle phase. CD10 was initially expressed in placode cells of fetal follicles and later in matrix cells, inner root sheath, and dermal sheath of mature follicles, while CD34 was expressed in dermal condensate mesenchymal cells of fetal follicles and in the external root sheath of adult anagen follicles. The expression of both proteins decreased or was not detected in the catagen and telogen phases. These findings suggest that CD10 and CD34 may play roles in hair follicle morphogenesis and could be markers for cells with the capacity to induce hair follicle formation, which is relevant for hair regeneration and hair loss therapies. The number of people involved in the study was not specified.
