Cutaneous Consequences of Inhibiting EGF Receptor Signaling In Vivo: Normal Hair Follicle Development, But Retarded Hair Cycle Induction and Inhibition of Adipocyte Growth in EgfrWa5 Mice

    January 2010 in “ Journal of Dermatological Science ”
    Koji Sugawara, Marlon R. Schneider, Maik Dahlhoff … Ralf Paus
    Studysummary In this study, Waved-5 mice with reduced EGFR signaling showed nearly normal skin and hair follicle function but experienced a transient reduction in subcutaneous fat.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on jdsjournal.com →
    Discuss this study in the Community →

    Research cited in this study 11

    1. Epigen Transgenic Mice Develop Enlarged Sebaceous Glands Journal of Investigative Dermatology · 2009
    2. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    3. Beyond Wavy Hairs: The Role of EGFR in Skin and Hair Biology American Journal Of Pathology · 2008
    4. Betacellulin Regulates Hair Follicle Development and Hair Cycle Induction and Enhances Angiogenesis in Wounded Skin Journal of Investigative Dermatology · 2007
    5. Topical Estrogen Accelerates Hair Regrowth in Mice After Chemotherapy-Induced Alopecia by Favoring the Dystrophic Catagen Response Pathway to Damage Journal of Investigative Dermatology · 2004
    6. Mice Humanized for the EGF Receptor Display Hypomorphic Phenotypes in Skin, Bone, and Heart Development · 2003
    7. Epidermal Growth Factor as a Biological Switch in Hair Growth Cycle Journal of biological chemistry/˜The œJournal of biological chemistry · 2003
    8. Genetically Null Mice Reveal a Central Role for Epidermal Growth Factor Receptor in the Differentiation of the Hair Follicle and Normal Hair Development PubMed · 1997
    9. Expression of a Dominant Negative Mutant of Epidermal Growth Factor Receptor in the Epidermis of Transgenic Mice Elicits Striking Alterations in Hair Follicle Development and Skin Structure. The EMBO Journal · 1995
    10. Effects of Epidermal Growth Factor on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1994
    11. Effects of Intradermally Injected and Topically Applied Mouse Epidermal Growth Factor on Wool Growth, Skin, and Wool Follicles of Merino Sheep Australian Journal of Biological Sciences · 1988

    Related research 6

    1. Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles Frontiers in Cell and Developmental Biology · 2022
    2. Dermal Papilla-Derived Wnt Ligands Are Required for Adult Hair Follicle Growth Journal of Investigative Dermatology · 2016
    3. Putting the Human Hair Follicle Cycle on the Map Journal of Investigative Dermatology · 2016
    4. Telogen Phase of Hair Growth Cycle Is Regulated by Cyclic Epithelial FGF18 Signaling Journal of Dermatological Science · 2012
    5. Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling Journal of Investigative Dermatology · 2012
    6. Expression of E6 and E7 Papillomavirus Oncogenes in the Outer Root Sheath of Hair Follicles Extends the Growth Phase and Bypasses Resting at Telogen PubMed · 2000