Beyond Wavy Hairs: The Role of EGFR in Skin and Hair Biology

The document reviewed the role of the epidermal growth factor receptor (EGFR) network in skin biology and pathology, emphasizing its critical function in cellular processes such as proliferation, differentiation, and wound healing, as well as its involvement in hair follicle morphogenesis and tumorigenesis. Genetically modified mouse models with mutations in the EGFR system exhibited phenotypes like alopecia, psoriasis-like lesions, and skin tumors, highlighting the impact of EGFR signaling on hair structure and skin homeostasis. The review also discussed the roles of EGFR ligands and ERBB2 in skin conditions and cancer, noting that overexpression or deficiency of specific ligands led to various skin conditions and that EGFR signaling was crucial for normal development and tissue homeostasis. The findings suggested potential therapeutic targets for skin diseases and cancer, emphasizing the complex interactions of these receptors and ligands in skin and hair biology.