Beyond Wavy Hairs: The Role of EGFR in Skin and Hair Biology

    June 2008 in “ American Journal Of Pathology ”
    Marlon R. Schneider, Sabine Werner, Ralf Paus, Eckhard Wolf
    Studysummary This review discusses the effects of the epidermal growth factor receptor system on skin biology and pathology, relying on animal models to analyze roles in cellular processes, wound healing, and tumorigenesis, but reports no new results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on ajp.amjpathol.org →
    Discuss this study in the Community →

    Research cited in this study 17

    1. Betacellulin Regulates Hair Follicle Development and Hair Cycle Induction and Enhances Angiogenesis in Wounded Skin Journal of Investigative Dermatology · 2007
    2. Mice Humanized for the EGF Receptor Display Hypomorphic Phenotypes in Skin, Bone, and Heart Development · 2003
    3. Epidermal Growth Factor as a Biological Switch in Hair Growth Cycle Journal of biological chemistry/˜The œJournal of biological chemistry · 2003
    4. Endogenous Production of Heparin-Binding EGF-Like Growth Factor During Murine Partial-Thickness Burn Wound Healing Journal of Burn Care & Rehabilitation · 2002
    5. Conditional Expression of the ErbB2 Oncogene Elicits Reversible Hyperplasia in Stratified Epithelia and Up-Regulation of TGFα Expression in Transgenic Mice Oncogene · 1999
    6. Targeted Expression of Activated ErbB-2 to the Epidermis of Transgenic Mice Elicits Striking Developmental Abnormalities in the Epidermis and Hair Follicles PubMed · 1998
    7. Severe Follicular Hyperplasia and Spontaneous Papilloma Formation in Transgenic Mice Expressing the Neu Oncogene Under the Control of the Bovine Keratin 5 Promoter Molecular Carcinogenesis · 1998
    8. Genetically Null Mice Reveal a Central Role for Epidermal Growth Factor Receptor in the Differentiation of the Hair Follicle and Normal Hair Development PubMed · 1997
    9. Expression of a Dominant Negative Mutant of Epidermal Growth Factor Receptor in the Epidermis of Transgenic Mice Elicits Striking Alterations in Hair Follicle Development and Skin Structure. The EMBO Journal · 1995
    10. Effects of Epidermal Growth Factor on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1994
    11. Mice With a Null Mutation of the TGFα Gene Have Abnormal Skin Architecture, Wavy Hair, and Curly Whiskers and Often Develop Corneal Inflammation Cell · 1993
    12. Localization of Epidermal Growth Factor Immunoreactivity in Sheep Skin During Wool Follicle Development Journal of Investigative Dermatology · 1992
    13. Transgenic Mice Provide New Insights Into the Role of TGF-Alpha During Epidermal Development and Differentiation Genes & Development · 1991
    14. TGF-Alpha Is Widely Expressed in Differentiated as Well as Hyperproliferative Skin Epithelium Journal of Investigative Dermatology · 1991
    15. Comparison of Epidermal Growth Factor Binding and Receptor Distribution in Normal Human Epidermis and Epidermal Appendages Journal of Investigative Dermatology · 1984
    16. Distribution and Number of Epidermal Growth Factor Receptors in Skin Is Related to Epithelial Cell Growth Developmental Biology · 1983
    17. Epidermal Growth Factor Delays Development of Epidermis and Hair Follicles in Mice During First Coat Growth The Anatomical Record · 1983