Targeted Expression of Activated ErbB-2 to the Epidermis of Transgenic Mice Elicits Striking Developmental Abnormalities in the Epidermis and Hair Follicles

April 1998 in “ PubMed ”

Wen Xie, Xiaoli Wu, Louise T. Chow, E Chin, Andrew J. Paterson, Jeffrey E. Kudlow

erbB-2 proto-oncogene epidermal hyperplasia preneoplasia papilloma hair follicles squamous structures hyperplasia disorganization keratin 14 promoter

Studysummary This study found that activating the erbB-2 oncogene in transgenic mice led to severe skin abnormalities and fatal defects, indicating erbB-2's significant role in skin and hair follicle development.

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