Overexpression of Human Keratin 16 Produces a Distinct Skin Phenotype in Transgenic Mouse Skin

    September 1995 in “ Biochemistry and Cell Biology ”
    Pierre A. Coulombe, Nicola S. Bravo, Rudolph D. Paladini … Kenzo Takahashi
    Studysummary This study found that high levels of human cytokeratin 16 expression in transgenic mice lead to skin lesions and altered keratinocyte structure, suggesting potential implications for human skin disorders and wound healing.
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    Research cited in this study 7

    1. Relative Amounts of Keratin 17 Are Higher Than Those of Keratin 16 in Hair Follicle Derived Tumors Compared to Nonfollicular Epithelial Skin Tumors Journal of Investigative Dermatology · 1995
    2. Increased Expression of Keratin 16 Causes Anomalies in Cytoarchitecture and Keratinization in Transgenic Mouse Skin The Journal of Cell Biology · 1994
    3. Cyclic Hair Loss and Regrowth in Transgenic Mice Overexpressing an Intermediate Filament Gene The EMBO Journal · 1990
    4. A New Look Into an Old Problem: Keratins as Tools to Investigate Determination, Morphogenesis, and Differentiation in Skin Genes & Development · 1989
    5. A Group of Type I Keratin Genes on Human Chromosome 17: Characterization and Expression Molecular and Cellular Biology · 1988
    6. Keratins of the Human Hair Follicle: Hyperproliferative Keratins Consistently Expressed in Outer Root Sheath Cells In Vivo and In Vitro Differentiation · 1987
    7. Three cDNA Sequences of Mouse Type I Keratins: Cellular Localization of the mRNAs in Normal and Hyperproliferative Tissues Journal of Biological Chemistry · 1987

    Related research 2

    1. Analysis of Proliferation, Apoptosis, and Keratin Expression in Cultured Normal and Immortalized Human Buccal Keratinocytes European Journal Of Oral Sciences · 2003
    2. Keratin and Skin Disorders Cell biology international · 1996