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Glossary Proto-oncogene

normal gene involved in cell growth and division

A proto-oncogene is a normal gene that plays a role in cell growth and division. However, if this gene mutates or is expressed at high levels, it can become an oncogene, which may lead to uncontrolled cell growth and potentially cancer.

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Research

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research MYC Protooncogenes of Wool and Hair Growth^a

14 citations , December 1991 in “Annals of the New York Academy of Sciences”

This study reports that lower levels of N-myc mRNA are observed when hair growth ceases in certain phases in mice, and attempts to create transgenic mice for further investigation resulted in high embryonic mortality.

research WNT Signaling in the Control of Hair Growth and Structure

271 citations , March 1999 in “Developmental biology”

This study reveals that overexpression of Wnt3 in transgenic mouse skin leads to a short-hair phenotype and cyclical balding due to structural defects in hair shafts, highlighting a role for WNT signaling in hair growth regulation.

research Targeted expression of activated erbB-2 to the epidermis of transgenic mice elicits striking developmental abnormalities in the epidermis and hair follicles.

35 citations , April 1998 in “PubMed”

This study found that activating the erbB-2 oncogene in transgenic mice led to severe skin abnormalities and fatal defects, indicating erbB-2's significant role in skin and hair follicle development.

research The dual role of stem cell-specific Bcl-2 function for epidermal regeneration and cancer

September 2019

This study indicates that the protein Bcl-2 has a dual role, protecting hair follicle stem cells from apoptosis during regeneration and promoting tumor formation under oncogenic stress.

research Skin transcriptome analysis identifies the key genes underlying fur development in Chinese Tan sheep in the birth and Er-mao periods

12 citations , February 2022 in “Gene”

In this study, researchers found that the FOS gene may play a significant role in promoting hair follicle development in Tan sheep between birth and the Er-mao period.

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Community Join

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community Photo results of oral min have many got growth from it

in Progress Pictures 1 upvotes 1 year ago

The user is seeking before-and-after photos of hair growth results from using oral or topical Minoxidil, as they couldn't use Finasteride but are using RU58841. They are curious about the effectiveness of Minoxidil alone.

community Progress photo - 2 years on topical minoxidil.

6 upvotes 3 weeks ago

The user experienced crown thinning in their 30s and has been using topical minoxidil for 2 years with great regrowth results. Finasteride was not an option, and the user acknowledges minoxidil is not a permanent solution but is satisfied with the current hair stability.

community Progress photo shy of 1.5 years

in Progress Pictures 14 upvotes 2 years ago

User shared a progress photo after 1.5 years of using 1mg Finasteride daily, 5% Minoxidil twice daily, Nizoral shampoo and conditioner 2-3 times weekly, and derma stamping bi-weekly. The post is categorized under "Progress Pictures."

community dut doomers - any photo evidence of people regrowing AFTER going back to fin?

in Finasteride/Dutasteride 23 upvotes 11 months ago

Some users experience worsening hair loss with dutasteride and improvement after switching back to finasteride, while others find better results with dutasteride. The effectiveness of treatments like finasteride, dutasteride, minoxidil, and RU58841 varies, requiring individuals to try different combinations or dosages to find what works best.

community March 30 first photo yesterday other 2 pics 19 year old

in Is this regrowth? 15 upvotes 1 year ago

The user started using minoxidil and finasteride for hair loss treatment six months ago, with some improvement in mental health and manageable side effects. They are considering switching minoxidil brands due to dissatisfaction and are focusing on stress management and lifestyle changes to improve scalp health.

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Clinics

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Hair Loss TreatmentsHair Transplant
Proto ClinicDubai · AE

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