Identification of Key Genes and Signaling Pathways Related to Hetian Sheep Wool Density by RNA-Seq Technology

May 2022 in “ PLOS ONE ”

Ruijun Shi, Shuwei Li, Penggang Liu, Shuhui Zhang, Zhenhui Wu, Tsan-Ming Wu, Shujuan Gong, Yu Wan

Studysummary This study found that Hetian sheep with higher wool density produce more and finer wool, with key genes potentially influencing their wool growth and density.

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The research investigated wool density in Hetian sheep and found that sheep with high wool density produced finer wool. The study identified 1,452 differentially expressed genes (DEGs) that could influence wool density and quality. Key genes and signaling pathways, such as TGF-β/BMP and MAPK, were found to be related to hair growth. Eleven genes belonging to the KAPs and KIFs might affect the fineness of the wool. Key genes like TNF, MAP2K2, INHBA, FST, PTPN11, MAP3K7, KIT, and BMPR1A might affect wool growth and density. This research provides valuable resources for improving the wool quality and quantity of Hetian sheep.

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